Immunophenotypic Expression Pattern
|
Marker
|
Comment
|
|
Positive
|
|
|
Positive
|
|
|
Positive
|
|
|
Positive
|
|
|
Positive
|
|
|
Positive (often numerous reactive T-cells will be present)
|
|
|
Positive in the neoplastic cells in ~50% of cases
|
|
|
CXCL13
|
Positive in a majority of cases (marker of follicular helper T-cells)
|
|
EBV (EBER)
|
Positive in reactive B-cells
|
|
Negative
|
|
|
Expanded FDC network
|
It is not uncommon for some of the T-cell markers to be dropped.
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.