EBV+ DLBCL of the Elderly is an EBV expressing DLBCL in patients >50 years of age. Other lymphomas, which may express EBV, are excluded from this categorization. Most cases (70%) are extra nodal, while the remaining 30% have lymph node disease only.
Characteristic Immunophenotype
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Marker
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Comment
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Negative
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Positive. Cases with a plasmablastic differentiation may be negative.
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Positive
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EBV
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LMP-1 is expressed in 94% of cases. EBNA-2 expression is seen in ~28% of cases.
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EBER
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Positive
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Variable
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Negative
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Usually Negative
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Usually Negative
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References
Wong, HH. et. al. “Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly.” Leuk Lymhpoma 2009. Mar;50(3):335-40.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 243-4.