Primary Cutaneous DLBCL, Leg Type is an uncommon cutaneous lymphoma (<5% of cutaneous lymphomas), but and important entity to differentiate due to its aggressive course. Unlike other cutaneous B-cell lymphomas, which are generally indolent and treated locally, primary cutaneous DLBCL, leg type behaves in a similar fashion to the systemic DLBCL (intermediate grade lymphoma) and is treated as such.
Characteristic Immunophenotype
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Marker
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Comment
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Negative. T-cells are generally absent or found in a perivascular pattern.
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Positive
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Positive
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Strong expression in ~90% of cases.
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Strong expression in ~90% of cases.
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Expressed in a majority of cases.
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Usually Negative
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References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 242.