Primary CNS Lymphoma represents lymphoma restricted to the cerebral or ocular parenchyma. It represents <1% of non-Hodgkin lymphomas, and 2-3% of brain tumors.
Characteristic Immunophenotype
|
Marker
|
Comment
|
|
Negative
|
|
|
Positive
|
|
|
Positive
|
|
|
CD22
|
Positive
|
|
Expressed in ~10-20% of cases.
|
|
|
Expressed in 60-80% of cases.
|
|
|
Expressed in ~90% of cases.
|
|
|
Expressed in most cases
|
|
|
EBV (EBER)
|
Usually Negative
|
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 240-1.