PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following disease-HLA associations is incorrect?Sjogren syndrome – DR3Goodpasture’s disease – B35Ankylosing spondylitis – B27Type I diabetes mellitus – DR3, DR4Rheumatoid arthritis – DR4 2. Which one of the following statements best describes rheumatoid factor?It is an antibody against cellular DNAThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIt is an antibody against the Fab portion of IgGTest methodology is typically nephelometry or latex immunofixationIgA rheumatoid factor is associated with less severe disease 3. Which one of the following statements regarding IgD is false?Binds complement Does not cross the placenta About 1% of all serum immunoglobulins Does not bind to cells through its Fc region 4. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI and II onlyI onlyI, II, IIIAll of the aboveI, II, IV 5. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1 inhibitorC4C1C3 convertaseproperdin 6. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesAn anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Anti-CMV IgG present in the patient’s serum confirms acute CMV infection Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infection 7. Which one of the following statements regarding complement C3 is incorrect?Part of the membrane attack complex (MAC) Enzymatic cleavage yields an anaphylatoxin and an opsonin Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisPredominantly produced by the hepatocyteDeficiencies are associated with increased risk of meningococcal infection 8. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Hypocalcemia Deletions on chromosome 11q22 Cardiac abnormalitiesCleft palate Thymic aplasia 9. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area II represents the carboxy terminusArea III has bivalent binding capacityArea IV is a crystallizable fragment Area V is the site of pepsin cleavageArea III represents the constant domain 10. The HLA gene is present at which chromosomal location?22q6q3q3p6p 11. Which disease-hypersensitivity type association is incorrect?Transplant rejection – cell-mediated (type IV) Serum sickness – antibody-mediated (type II)Goodpasture syndrome -- antibody-mediated (type II) Bee sting allergy – immediate (type I)Systemic lupus erythematosus -- immune complex-mediated (type III) 12. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are found in the beta-2 regionSilver staining is more rapid, but less sensitive than Coomassie BlueOligoclonal bands are pathognomonic for MS A serum specimen must be run concurrently for comparisonTypically performed by SDS-PAGE 13. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Haptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromePeak V is consistent with a polyclonal gammopathyNone are correct 14. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, II, III All of the above I, II, IVII, III, IVI, III, IV Loading...
