PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C4C3 convertaseC1 inhibitorC1properdin 2. Which one of the following disease-HLA associations is incorrect?Ankylosing spondylitis – B27Goodpasture’s disease – B35Sjogren syndrome – DR3Rheumatoid arthritis – DR4Type I diabetes mellitus – DR3, DR4 3. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesIgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)Anti-CMV IgG present in the patient’s serum confirms acute CMV infection 4. The HLA gene is present at which chromosomal location?3q6p 6q22q3p 5. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, III, IVI, II, III I, II, IVAll of the above II, III, IV 6. Which one of the following statements best describes rheumatoid factor?The test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIgA rheumatoid factor is associated with less severe diseaseTest methodology is typically nephelometry or latex immunofixationIt is an antibody against the Fab portion of IgGIt is an antibody against cellular DNA 7. Which one of the following statements regarding complement C3 is incorrect?Predominantly produced by the hepatocyteElevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisDeficiencies are associated with increased risk of meningococcal infection Enzymatic cleavage yields an anaphylatoxin and an opsonin Part of the membrane attack complex (MAC) 8. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Cleft palate Cardiac abnormalitiesThymic aplasiaHypocalcemia Deletions on chromosome 11q22 9. Which disease-hypersensitivity type association is incorrect?Bee sting allergy – immediate (type I)Systemic lupus erythematosus -- immune complex-mediated (type III) Serum sickness – antibody-mediated (type II)Transplant rejection – cell-mediated (type IV) Goodpasture syndrome -- antibody-mediated (type II) 10. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area V is the site of pepsin cleavageArea III has bivalent binding capacityArea III represents the constant domain Area II represents the carboxy terminusArea IV is a crystallizable fragment 11. Which one of the following statements regarding IgD is false?About 1% of all serum immunoglobulins Binds complement Does not cross the placenta Does not bind to cells through its Fc region 12. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI, II, IVAll of the aboveI and II onlyI onlyI, II, III 13. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Typically performed by SDS-PAGE Oligoclonal bands are pathognomonic for MS Silver staining is more rapid, but less sensitive than Coomassie BlueA serum specimen must be run concurrently for comparisonOligoclonal bands are found in the beta-2 region 14. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Peak V is consistent with a polyclonal gammopathyNone are correctPeak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromeHaptoglobin is normally a component of peak II Loading...
