PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is true regarding acute neuronal injury?Eosinophilic neuronal necrosis is the earliest light microscopic signRed neurons can be seen as early as 2 hours after injury Healing neurons can be identified as chromatolyticIt can be reversible if detected by brain biopsy It represents the typical injury pattern associated with toxic-metabolic insults 2. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13Most are WHO Grade II; however, some can be WHO Grade IV Microcalcifications are helpful to the diagnosis, but are present in only 20 % of casesClear cytoplasm due to glycogen accumulation is typical If identified, losses of 1p and 19q indicate better response to treatment It has a high propensity to infiltrate the leptomeninges, since most arise in the cortex 3. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Causes temporary neurological deficits that leads to death within a period of 8 to 12 yearsRequires electron microscopic examination for definitive diagnosisProduces a granulomatous reaction in most casesTypically involves the temporal lobe Is of unknown etiology 4. Which of the following types of meningioma has the worst prognosis based on histological features?SecretoryRhabdoidFibroblasticChordoidMetaplastic 5. Which of the following is correct regarding the central nervous system tumors?Hematogenous spread is common in high grade tumors due to vascular proliferation The annual incidence is 2/100,000 for intracranial tumors Biologic behavior does not necessarily correlate with histologyMeningioma is the most common primary brain tumor Supratentorial tumors are common in children 6. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Can lead to cerebellar dysfunction in about 20% of casesIs the result of an acute intoxicationIs the result of chronic methanol intoxication Predominantly affects granule cell layerIs reversible with intensive therapy 7. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4An organized abscess cavity Is an acute hemorrhage Is encephalomalacia due to trauma Is a remote intraparenchymal hematoma secondary to traumaIs a remote infarct with hemorrhagic component 8. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?Chronic lymphocytic leukemiaToxoplasmosisCryptococcosisGlioblastomaMultiple sclerosis 9. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9This feature is pathognomonic for this disease process Definitive diagnosis is by autopsyMost common location for this finding is cerebellumIt presents with rapidly progressing dementiaGross examination of the brain rarely provides any clues 10. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14It has a high propensity to infiltrate throughout the brain parenchymaThis is an undifferentiated tumor, although neuronal and glial markers can be expressedLosses of 22p is the most common genetic alterationThis is a highly malignant tumor with 5-year survival rate of less than 10%The most common location is the pineal region of young adults 11. Which of the following cell types originate outside the central nervous system?Neurons of the dentate gyrusOligodendrogliocytesAstrocytesMicrogliocytesEpendymocytes 12. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12It is a relatively well-circumscribed tumor, rendering gross total resection possible It is considered as a WHO Grade II tumor It typically occurs in the cerebral hemispheres in the elderlyIn spite of gross total resection, the prognosis is grim Typical gross appearance is a solid, well-circumscribed mass 13. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It is a rare disorder in this age groupPresents with typical initial neurological signs and symptomsIt is a dysmyelinating processIt is characterized by multiple lesions of various agesIt most commonly involves basal ganglia 14. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3Spinal cord is unaffectedIt is due to hindbrain abnormalitiesCerebellum, brain stem and pituitary gland may be unaffectedIt occurs due to problems within the 3rd month of gestationIt is usually associated with iris abnormalities 15. Based on this image, this process: Neuropathology - Part 1, Question #7Is highly contagious among medical personnel Is primarily sporadicIs difficult to suspect due to ill-defined clinical picture Is a specific form of viral encephalopathy Evolves within a span of decades, with eventual death Loading...
