PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?Chronic lymphocytic leukemiaCryptococcosisGlioblastomaToxoplasmosisMultiple sclerosis 2. Based on this image, this process: Neuropathology - Part 1, Question #7Evolves within a span of decades, with eventual deathIs highly contagious among medical personnel Is primarily sporadicIs a specific form of viral encephalopathy Is difficult to suspect due to ill-defined clinical picture 3. Which of the following is correct regarding the central nervous system tumors?The annual incidence is 2/100,000 for intracranial tumors Hematogenous spread is common in high grade tumors due to vascular proliferation Biologic behavior does not necessarily correlate with histologyMeningioma is the most common primary brain tumor Supratentorial tumors are common in children 4. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14The most common location is the pineal region of young adultsLosses of 22p is the most common genetic alterationThis is a highly malignant tumor with 5-year survival rate of less than 10%This is an undifferentiated tumor, although neuronal and glial markers can be expressedIt has a high propensity to infiltrate throughout the brain parenchyma 5. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It most commonly involves basal ganglia It is characterized by multiple lesions of various agesPresents with typical initial neurological signs and symptomsIt is a rare disorder in this age groupIt is a dysmyelinating process 6. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Causes temporary neurological deficits that leads to death within a period of 8 to 12 yearsIs of unknown etiologyRequires electron microscopic examination for definitive diagnosisTypically involves the temporal lobe Produces a granulomatous reaction in most cases 7. Which of the following types of meningioma has the worst prognosis based on histological features?MetaplasticFibroblasticChordoidSecretoryRhabdoid 8. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9It presents with rapidly progressing dementiaThis feature is pathognomonic for this disease process Definitive diagnosis is by autopsyGross examination of the brain rarely provides any clues Most common location for this finding is cerebellum 9. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3It is usually associated with iris abnormalitiesIt is due to hindbrain abnormalitiesCerebellum, brain stem and pituitary gland may be unaffectedSpinal cord is unaffectedIt occurs due to problems within the 3rd month of gestation 10. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4An organized abscess cavity Is an acute hemorrhage Is a remote infarct with hemorrhagic component Is a remote intraparenchymal hematoma secondary to traumaIs encephalomalacia due to trauma 11. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13Microcalcifications are helpful to the diagnosis, but are present in only 20 % of casesIt has a high propensity to infiltrate the leptomeninges, since most arise in the cortexClear cytoplasm due to glycogen accumulation is typical If identified, losses of 1p and 19q indicate better response to treatment Most are WHO Grade II; however, some can be WHO Grade IV 12. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12Typical gross appearance is a solid, well-circumscribed mass In spite of gross total resection, the prognosis is grim It is a relatively well-circumscribed tumor, rendering gross total resection possible It typically occurs in the cerebral hemispheres in the elderlyIt is considered as a WHO Grade II tumor 13. Which of the following cell types originate outside the central nervous system?OligodendrogliocytesAstrocytesMicrogliocytesEpendymocytesNeurons of the dentate gyrus 14. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Predominantly affects granule cell layerIs the result of an acute intoxicationCan lead to cerebellar dysfunction in about 20% of casesIs the result of chronic methanol intoxication Is reversible with intensive therapy 15. Which of the following is true regarding acute neuronal injury?It can be reversible if detected by brain biopsy Red neurons can be seen as early as 2 hours after injury Healing neurons can be identified as chromatolyticEosinophilic neuronal necrosis is the earliest light microscopic signIt represents the typical injury pattern associated with toxic-metabolic insults Loading...
