PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1MelanomaMesotheliomaSchwannomaAdenocarcinomaSquamous Cell Carcinoma 2. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?S-100 Hale’s colloidal ironSynaptophysinCD45CD138 3. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show cytoplasmic microvilli EM will show abundant rough endoplasmic reticulum EM will show numerous lysosomesEM will show numerous premelanosomes EM will show abundant mitochondria 4. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:SchwannomaAstrocytomaCarcinomaEpendymomaChoroid plexus tumor 5. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5Granular Cell Tumor Renal Cell Carcinoma, clear cell typeMelanomaRenal Cell Carcinoma, chromophobe type Oncocytoma 6. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:Prostate carcinoma Breast adenocarcinoma Thyroid follicular carcinoma MesotheliomaPulmonary adenocarcinoma 7. A specimen being prepared for electron microscopy should be fixed in:Zinc formalin Mercury based fixativeBouin’sB5Gluteraldehyde 8. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3MesotheliomaAdenocarcinomaMelanomaSquamous Cell Carcinoma Schwannoma 9. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4MeningiomaSchwannomaLymphomaAdenocarcinomaSquamous Cell Carcinoma 10. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:Thyroid follicular carcinoma GI adenocarcinoma Breast adenocarcinoma MesotheliomaProstate carcinoma 11. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:EpendymomaMeningiomaLymphomaSchwannomaCarcinoma 12. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2Granular Cell Tumor SchwannomaPlasmacytomaAdenocarcinomaMelanoma 13. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?Clear cell sarcomaAlveolar soft part sarcoma MedulloblastomaNeurocytomaPapillary ependymoma Loading...