PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?NeurocytomaClear cell sarcomaAlveolar soft part sarcoma MedulloblastomaPapillary ependymoma 2. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2SchwannomaPlasmacytomaAdenocarcinomaMelanomaGranular Cell Tumor 3. A specimen being prepared for electron microscopy should be fixed in:GluteraldehydeZinc formalin Mercury based fixativeBouin’sB5 4. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3MelanomaSchwannomaMesotheliomaSquamous Cell Carcinoma Adenocarcinoma 5. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?Hale’s colloidal ironSynaptophysinS-100 CD45CD138 6. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:Choroid plexus tumorEpendymomaSchwannomaAstrocytomaCarcinoma 7. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4MeningiomaSchwannomaLymphomaSquamous Cell Carcinoma Adenocarcinoma 8. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show abundant mitochondria EM will show abundant rough endoplasmic reticulum EM will show numerous premelanosomes EM will show numerous lysosomesEM will show cytoplasmic microvilli 9. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:MeningiomaEpendymomaCarcinomaSchwannomaLymphoma 10. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:MesotheliomaBreast adenocarcinoma Pulmonary adenocarcinomaProstate carcinoma Thyroid follicular carcinoma 11. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1Squamous Cell Carcinoma AdenocarcinomaSchwannomaMesotheliomaMelanoma 12. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:GI adenocarcinoma Breast adenocarcinoma Thyroid follicular carcinoma MesotheliomaProstate carcinoma 13. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5Renal Cell Carcinoma, clear cell typeRenal Cell Carcinoma, chromophobe type Granular Cell Tumor OncocytomaMelanoma Loading...