PathMD Quizes, Hematopathology Spleen – 01 October 29, 2017 peferguson Author: Philip Ferguson, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. The images for this case are from a 1,000 gram spleen from a 75 year old man. Special stains were positive for CD45 and CD20, but negative for CD3 and CD15. Based on these findings, the best diagnosis is: Spleen Part 1, Case #8 Spleen Part 1, Case #8 Spleen Part 1, Case #8MelanomaAnaplastic DLBCL Immunoblastic DLBCLAnaplastic Large Cell LymphomaHodgkin’s Lymphoma 2. The images for this case come from an elderly female with a history of an autoimmune disorder. The spleen was 1,500 grams and noted to have “tumor nodules”. Based on the findings, the best diagnosis is: Spleen Part 1, Case #4 Spleen Part 1, Case #4 Spleen Part 1, Case #4HemangiomaKaposi’s SarcomaAngiosarcomaLittoral Cell Angioma Leiomyosarcoma 3. A 4,000 gram spleen was removed from a man and has the histology presented for this case in the images below. Special stains were performed. The cells of interest were positive for CD68 and negative for S-100, CD1a, and PAS. Based on these findings, the best diagnosis is: Spleen Part 1, Case #2 Spleen Part 1, Case #2 Spleen Part 1, Case #2Whipple’s disease Langerhan Cell Histiocytosis Gaucher diseaseRosai-Dorfman disease Splenic Marginal Zone Lymphoma 4. The images associated with this case are from a moderately enlarged spleen in an individual with a WBC count greater than 150,000. The flow cytometry profile showed the population to express CD13, CD33, and CD117. Based on the morphology and flow cytometry, the best diagnosis is: Spleen Part 1, Case #1 Spleen Part 1, Case #1 Spleen Part 1, Case #1CLL/SLL CMLAMLHairy Cell Leukemia ALL 5. The images for this case come from a 60 year old man with an enlarged spleen and a hilar mass. Based on the information, the best diagnosis is: Spleen Part 1, Case #3 Spleen Part 1, Case #3 Spleen Part 1, Case #3Large Cell Neuroendocrine Carcinoma Anaplastic Large Cell Lymphoma Hodgkin’s Lymphoma MelanomaLarge Cell Lymphoma 6. Images for this case come from a spleen in a 60 year old male with a ruptured spleen. Special stains showed positivity for CD20, bcl-1, and CD43. Based on these findings, the best diagnosis is: Spleen Part 1, Case #5 Spleen Part 1, Case #5 Spleen Part 1, Case #5CLL/SLLMarginal Zone Lymphoma Diffuse Large B-Cell LymphomaFollicular Lymphoma Mantle Cell Lymphoma 7. These images are of a 1,000 gram spleen from a patient with multiple episodes of hemolysis resistant to steroids. Based on the images and the patient’s history, the best diagnosis is: Spleen Part 1, Case #6 Spleen Part 1, Case #6Felty syndromeKasabach-Merritt phenomenonCongestion secondary to increased venous pressureCongestion secondary to AIHA 8. These images are from the spleen of a 30 y/o pregnant patient. The spleen weighed 2,000 grams. Stains for AFB and fungi were negative. The best diagnosis is: Spleen Part 1, Case #7 Spleen Part 1, Case #7Necrotizing granulomatous splenitis LeishmaniasisSarcoidosisTBAmyloidosis Loading...