PathMD Quizes, Neuropathology Neuropathology – 02 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2Bilateral schwannomas are also present in volving the 8th. nerve It has a higher rate of progression to malignancy compared to general population It is associated with an abnormality in 22q It is associated with an autosomal-recessive disorder It is associated with one of the rarest form of genetic disorders 2. Which of the following lesions may be found together with the lesion shown in the picture? (SEGCA) Neuropathology Set 2 Neuropathology Set 2Pericardial cyst GlioblastomaSubungual angioma Cardiac rhabdomyoma Renal cell carcinoma 3. Which of the following is correct regarding the lesion shown in this picture? Neuropathology Set 2It is the second most common type of intracranial aneurysm The most common location is posterior cerebral artery branches It is the most common cause of subarachnoid hemorrhageit is usually located at the bending points of arteries bleeding is typically associated with incipient leakage 4. Which of the following is correct regarding hypertensive central nervous system hemorrhage?periventricular white matter is the preferred site for hemorrhagemany cases are associated with congophilic angiopathy it is the second most common cause of subdural hemorrhage Charcot-Bouchard aneurysms are thought to be the site of hemorrhage it comprises approximately 1/3 of all intraparenchymal brain hemorrhages 5. Which of the following is true regarding the lesion in this picture? Neuropathology Set 2It is typically located in the brainstem Its immunophenotype is essentially identical to renal cell carcinoma in many cases It usually presents as a highly infiltrative tumor, but paradoxically has a good prognosis It may be associated with renal cell carcinoma It is a highly malignant brain tumor with frequent dissemination to cerbrospinal axis 6. Which of the following pairs is correct?Kerns- Sayre syndrome- mitochondrial tRNA Metachromatic leukodystrophy- arylsulfatase A Adrenoleukodystrophy- long chain fatty acids Amyotrophic lateral sclerosis- trinucleotide repeatsVitamin B1 deficiency- subacute combined degenration of the spinal cord 7. While walking home after a party where he consumed five cans of beer, a previously healthy 28 year-old man fell and hit his head on the curb. He got up and went home. Later that night, he became unconscious and was brought to the emergency room by his roommate. Physical exam showed swelling of left temporalparietal area. What is the most likely explanation to his condition?Left cerebral artery rupture Right meningeal artery rupture Rupture of an anterior communicating artery aneurysmLeft meningeal artery rupturePreviously asymptomatic bacterial meningitis 8. Which of the following is correct regarding HIV and central nervous system?opportunistic infections are more commonly seen in the pediatric patient population spinal cord involvement presents as transverse myelitis due to opportunistic Herpes virus infectionCJD caused by opportunistic JC virus infection is a rare but serious complication diagnostic feature is intense lymphocytic infiltrates in the brain parenchyma and in the leptomeningesapproximately 60% of AIDS patients develop neurologic dysfuntion in the course of their disease 9. Which of the following is true regarding the disease process shown in the picture? Neuropathology Set 2This disease can easily be suspected in neonates by gross examinationThis picture is most likely from caudate nucleus This disease most commonly involves ageing neurons with lipofucsin pigment Structures with similar name, but with different microscopic appearance can be seen in cortical neurons and are easily demonstrated by synuclein immunohistochemistry Increase in serotonin levels is the major abnormality 10. Duret hemorrhages:occur in association with subfalcine herniationaccompany cerebellar mass lesions are the most common cause of aqueductal stenosis are seen in midbrain and ponsare secondary to middle meningeal artery tears 11. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2 Neuropathology Set 2Spinal cord is the most common location in childrenCerebrospinal fluid dissemination is common 1p/19q losses indicate worse prognosis GFAP has a peculiar perinuclear positivityIt is usually seen in the temporal lobe 12. A 29 year old man was found dead in the street. Autopsy showed hemorrhage under occipital scalp, and contusions of both occipital poles. Which of the following is the most likely explanation?Intracranial hemorrhage secondary to hypertensionHe was previously strangled to death and later the body was dumped in a remote street, at which time his head his the concrete pavement Slipped and fell on his back, hitting his head to concrete pavement He was attacked and was hit on the back of his head by a baseball bat Metastatic lung cancer secondary to heavy smoking 13. Which of the following is true regarding pituitary adenomas?Reticulin stain is a very useful technique for the differential diagnosis of normal pituitary gland vs. hyperplasia vs. adenoma Nelson syndrome is associated with gonadotroph adenomas Invasive adenomas have high probability of distant metastasesPituitary apoplexy is a postpartum neurosurgical emergency Growth hormone adenoma is the most common type 14. Which of the following is true regarding neursyphilis?Tabes dorsalis is the type that leads to dementia Paretic neurosyphilis is aseptic and is an immune reaction to bacterial components Meningovascular form is associated with obliterative endarteritis of the meninges It occurs in the secondary stage of the disease Neurosyphilis occurs in approximately half of untreated and 10% of treated patients 15. Which of the following is true regarding the disease shown in the picture? Neuropathology Set 2S. pneumoniae is the most common cause in adolescents cerebrospinal fluid shows increased lymphocytes and normal glucose levelit may result in hydrocephalusit represents diffuse involvement of meninges by malignancyE. coli is the most common cause in the elderly Loading...
