PathMD Quizes, Neuropathology Neuropathology – 02 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is true regarding pituitary adenomas?Growth hormone adenoma is the most common type Nelson syndrome is associated with gonadotroph adenomas Invasive adenomas have high probability of distant metastasesReticulin stain is a very useful technique for the differential diagnosis of normal pituitary gland vs. hyperplasia vs. adenoma Pituitary apoplexy is a postpartum neurosurgical emergency 2. While walking home after a party where he consumed five cans of beer, a previously healthy 28 year-old man fell and hit his head on the curb. He got up and went home. Later that night, he became unconscious and was brought to the emergency room by his roommate. Physical exam showed swelling of left temporalparietal area. What is the most likely explanation to his condition?Right meningeal artery rupture Rupture of an anterior communicating artery aneurysmLeft meningeal artery rupturePreviously asymptomatic bacterial meningitis Left cerebral artery rupture 3. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2It is associated with an autosomal-recessive disorder It is associated with an abnormality in 22q It is associated with one of the rarest form of genetic disorders It has a higher rate of progression to malignancy compared to general population Bilateral schwannomas are also present in volving the 8th. nerve 4. Which of the following pairs is correct?Adrenoleukodystrophy- long chain fatty acids Amyotrophic lateral sclerosis- trinucleotide repeatsVitamin B1 deficiency- subacute combined degenration of the spinal cord Kerns- Sayre syndrome- mitochondrial tRNA Metachromatic leukodystrophy- arylsulfatase A 5. Which of the following is true regarding the lesion in this picture? Neuropathology Set 2Its immunophenotype is essentially identical to renal cell carcinoma in many cases It may be associated with renal cell carcinoma It usually presents as a highly infiltrative tumor, but paradoxically has a good prognosis It is a highly malignant brain tumor with frequent dissemination to cerbrospinal axis It is typically located in the brainstem 6. Which of the following is true regarding the disease process shown in the picture? Neuropathology Set 2This disease can easily be suspected in neonates by gross examinationThis picture is most likely from caudate nucleus Structures with similar name, but with different microscopic appearance can be seen in cortical neurons and are easily demonstrated by synuclein immunohistochemistry This disease most commonly involves ageing neurons with lipofucsin pigment Increase in serotonin levels is the major abnormality 7. A 29 year old man was found dead in the street. Autopsy showed hemorrhage under occipital scalp, and contusions of both occipital poles. Which of the following is the most likely explanation?Metastatic lung cancer secondary to heavy smoking Intracranial hemorrhage secondary to hypertensionSlipped and fell on his back, hitting his head to concrete pavement He was previously strangled to death and later the body was dumped in a remote street, at which time his head his the concrete pavement He was attacked and was hit on the back of his head by a baseball bat 8. Which of the following lesions may be found together with the lesion shown in the picture? (SEGCA) Neuropathology Set 2 Neuropathology Set 2GlioblastomaPericardial cyst Renal cell carcinoma Cardiac rhabdomyoma Subungual angioma 9. Which of the following is correct regarding hypertensive central nervous system hemorrhage?Charcot-Bouchard aneurysms are thought to be the site of hemorrhage periventricular white matter is the preferred site for hemorrhagemany cases are associated with congophilic angiopathy it is the second most common cause of subdural hemorrhage it comprises approximately 1/3 of all intraparenchymal brain hemorrhages 10. Which of the following is correct regarding HIV and central nervous system?approximately 60% of AIDS patients develop neurologic dysfuntion in the course of their diseasediagnostic feature is intense lymphocytic infiltrates in the brain parenchyma and in the leptomeningesCJD caused by opportunistic JC virus infection is a rare but serious complication spinal cord involvement presents as transverse myelitis due to opportunistic Herpes virus infectionopportunistic infections are more commonly seen in the pediatric patient population 11. Which of the following is true regarding the disease shown in the picture? Neuropathology Set 2cerebrospinal fluid shows increased lymphocytes and normal glucose levelE. coli is the most common cause in the elderly S. pneumoniae is the most common cause in adolescents it may result in hydrocephalusit represents diffuse involvement of meninges by malignancy 12. Duret hemorrhages:are secondary to middle meningeal artery tearsare seen in midbrain and ponsoccur in association with subfalcine herniationaccompany cerebellar mass lesions are the most common cause of aqueductal stenosis 13. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2 Neuropathology Set 2Cerebrospinal fluid dissemination is common GFAP has a peculiar perinuclear positivityIt is usually seen in the temporal lobe 1p/19q losses indicate worse prognosis Spinal cord is the most common location in children 14. Which of the following is true regarding neursyphilis?Neurosyphilis occurs in approximately half of untreated and 10% of treated patients It occurs in the secondary stage of the disease Meningovascular form is associated with obliterative endarteritis of the meninges Tabes dorsalis is the type that leads to dementia Paretic neurosyphilis is aseptic and is an immune reaction to bacterial components 15. Which of the following is correct regarding the lesion shown in this picture? Neuropathology Set 2It is the most common cause of subarachnoid hemorrhageIt is the second most common type of intracranial aneurysm bleeding is typically associated with incipient leakage it is usually located at the bending points of arteries The most common location is posterior cerebral artery branches Loading...
