PathMD Quizes, Hematopathology Hematopathology – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. AML-M3 is characterized by?20% of more promyelocytes 50% of more erythroid precursors >90% myeloblasts of non-erythroid cells < 3% myeloperoxidase positive myeloblasts 20-80% immature monocytes 2. Which of the following characteristics is the most important defining feature of AML-M1?20% of more promyelocytes < 3% myeloperoxidase positive myeloblasts 20-80% immature monocytes 50% of more erythroid precursors >90% myeloblasts of non-erythroid cells 3. Which of the following characteristics is the most important defining feature of AML-M0?20% of more promyelocytes >90% myeloblasts of non-erythroid cells < 3% myeloperoxidase positive myeloblasts 50% of more erythroid precursors 20-80% immature monocytes 4. Which of the following characteristics is the most important defining feature of AML-M2?20-80% immature monocytes 50% of more erythroid precursors < 3% myeloperoxidase positive myeloblasts maturation of at least 10% of non-erythroid cells 20% of more promyelocytes 5. A 40 y/o man presents with isolated inguinal lymphadenopathy. An excisional biopsy is performed. Representative sections and special stains are shown. Based on the findings, what is the best diagnosis? Hematopathology - Part 2, Case #3 Hematopathology - Part 2, Case #3 Hematopathology - Part 2, Case #3. BCL-2 IHC stain.Cat-scratch lymphadenitis Follicular lymphomaReactive follicular hyperplasia Burkitt lymphoma Mantle cell lymphoma 6. Based on the morphologic findings of the peripheral blood smear for this question, which of the following is the best diagnosis? Hematopathology - Part 2, Case #5 Hematopathology - Part 2, Case #5 Hematopathology - Part 2, Case #5Alpha ThalassemiaHemoglobin SCLiver DiseaseHereditary SpherocytosisHemoglobin SS 7. A 50 y/o male presents with nasal obstruction. A biopsy is performed and representative sections are shown. The cells of interest are positive for CD56 and EBV by in situ hybridization (EBER). Based on these findings, what is the best diagnosis? Hematopathology - Part 2, Case #1 Hematopathology - Part 2, Case #1 Hematopathology - Part 2, Case #1Extranodal NK/T-cell lymphomaAngio-immunoblastic T-cell lymphomaT-cell ALLT-cell lymphoma, unspecified Wegner’s granulomatosis 8. A 50-year-old male presents with mild splenomegaly and circulating atypical lymphocytes. Flow cytometry identifies a CD20 positive, CD5 and CD10 negative kappa restricted lymphoid population. Based on the morphologic and flow cytometry findings, which of the following is the best diagnosis? Hematopathology - Part 2, Case #6 Hematopathology - Part 2, Case #6 Hematopathology - Part 2, Case #6Circulating follicular lymphoma Extranodal marginal zone lymphoma Chronic lymphocytic leukemia/lymphoma Mantle cell lymphoma Splenic marginal zone lymphoma 9. A cervical lymph node is biopsied from a 25 y/o man. Representative histology from the lymph node is shown. Based on the findings, what is the expected immunohistochemistry profile? Hematopathology - Part 2, Case #2 Hematopathology - Part 2, Case #2 Hematopathology - Part 2, Case #2CD15 +, CD20 +, CD 30 +, CD45 + CD15 +, CD20 +, CD 30 =, CD45 = CD15 +, CD20 =, CD 30 +, CD45 +CD15 +, CD20 +, CD 30 +, CD45 = CD15 +, CD20 =, CD 30 +, CD45 = 10. A soft tissue mass is found in the breast of a 45 y/o female that was thought to probably represent breast carcinoma. Representative images are shown. The histiocytic cells are positive for S-100 and negative for CD1a. Based on the findings, what is the best diagnosis? Hematopathology - Part 2, Case #4 Hematopathology - Part 2, Case #4Histiocytosis X Rosai-Dorfman disease Malignant melanoma PlasmacytomaLangerhan’s cell histiocytosis Loading...
