PathMD Quizes, GU Pathology GU Pathology – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. The following statements regarding normal prostate are true, EXCEPT:Lipofuscin pigment helps differentiate seminal vesicle tissue from prostatic glands Large number of neuroendocrine cells are present in prostatic epitheliumDenonvillier's fascia separates the prostate and seminal vesicles from the rectum Skeletal muscle of the urogenital diaphragm extends into the prostate in its most apical aspectAnterior fibromuscular stroma occupies approximately 1/3 of the prostate, contains very few glands and consists of smooth muscle and dense fibrous tissue 2. If seen on a prostate core biopsy this prostatic adenocarcinoma would be best graded as Gleason score =3 for 60%, Gleason score = 4 for 25%, and Gleason score = 5 for 15%. How would the case be scored overall?Gleason score 3 + 5 = 8/10 Gleason score 4 + 5 = 9/10 Gleason score 5 + 3 = 8/10 Gleason score 3 + 3 = 6/10 Gleason score 3 + 4 = 7/10 3. This subtype of prostatic carcinoma overall has a better prognosis than the usual acinar type:Small cell carcinomaSignet ring carcinoma Ductal carcinomaMucinous adenocarcinoma Adenoid basal cell tumor (adenoid cystic tumor) 4. A 42 yo female presented with hypertension, Cushing's syndrome and virilization. A representative section from her resection specimen is consistent with an adrenal cortical carcinoma. All of the following features are part of diagnostic criteria for this tumor EXCEPT:Vascular invasionTumor necrosis Diffuse growth patternCellular pleomorphismTumor weight 5. All of the following statements are correct regarding this kidney neoplasm, EXCEPT: GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5Staging is the most important prognostic determinator It always has three components: undifferentiated blastema, mesenchymal tissue and epithelial tissue90% of the cases occur before the age of 6 It is associated with Beckwith-Wiedemann and Denys-Drash syndromes Lesions are divided into favorable and unfavorable histology groups based on the degree of anaplasia 6. A 3 year old boy presents with a large abdominal mass consistent with neuroblastoma. All of the following statements regarding this condition are correct, EXCEPT:Histologically, the most prominent feature is presence of Homer Wright rosettesHemorrhage, calcification and necrosis are common macroscopic features Over 80% are detected in children under the age of 4 It is associated with the Beckwith-Wiedemann syndrome, Hirschsprung's disease and neurofibromatosisTwo characteristic genetic events are loss of a distal region of chromosome 1p and amplification of N-myc oncogene 7. All of the statements concerning a fibroepithelial polyp of the bladder are true, EXCEPT:It is mostly found in children and young adults There is a female predominanceIt represents a mesenchymal tumor This lesion has no malignant potential It occurs most commonly at the ureteropelvic junction and upper ureter 8. All of the following parameters are associated with adverse outcome in prostatic carcinoma, EXCEPT:Extraprostatic extensionPerineural invasion Positive surgical marginsInvolvement of seminal vesicle Nodal metastases 9. 63 year old male with a history of bilateral ocular MALT lymphoma treated with radiation therapy. He now presents with diffuse pelvic infiltrative process involving the bladder, prostate, seminal vesicles, rectosigmoid, distal ureters, and adjacent muscles. Bladder and prostate biopsies were performed. Based on histology, the process is most consistent with:Recurrent MALT lymphoma High grade prostatic adenocarcinoma Idiopathic retroperitoneal fibrosis High-grade lymphoma Invasive transitional cell carcinoma (urothelial neoplasm) Loading...