PathMD Quizes, GU Pathology GU Pathology – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A 42 yo female presented with hypertension, Cushing's syndrome and virilization. A representative section from her resection specimen is consistent with an adrenal cortical carcinoma. All of the following features are part of diagnostic criteria for this tumor EXCEPT:Diffuse growth patternTumor necrosis Tumor weightVascular invasionCellular pleomorphism 2. All of the following statements are correct regarding this kidney neoplasm, EXCEPT: GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5Staging is the most important prognostic determinator It always has three components: undifferentiated blastema, mesenchymal tissue and epithelial tissue90% of the cases occur before the age of 6 It is associated with Beckwith-Wiedemann and Denys-Drash syndromes Lesions are divided into favorable and unfavorable histology groups based on the degree of anaplasia 3. 63 year old male with a history of bilateral ocular MALT lymphoma treated with radiation therapy. He now presents with diffuse pelvic infiltrative process involving the bladder, prostate, seminal vesicles, rectosigmoid, distal ureters, and adjacent muscles. Bladder and prostate biopsies were performed. Based on histology, the process is most consistent with:High grade prostatic adenocarcinoma Recurrent MALT lymphoma High-grade lymphoma Invasive transitional cell carcinoma (urothelial neoplasm) Idiopathic retroperitoneal fibrosis 4. All of the statements concerning a fibroepithelial polyp of the bladder are true, EXCEPT:It occurs most commonly at the ureteropelvic junction and upper ureter It represents a mesenchymal tumor There is a female predominanceIt is mostly found in children and young adults This lesion has no malignant potential 5. A 3 year old boy presents with a large abdominal mass consistent with neuroblastoma. All of the following statements regarding this condition are correct, EXCEPT:Over 80% are detected in children under the age of 4 Histologically, the most prominent feature is presence of Homer Wright rosettesTwo characteristic genetic events are loss of a distal region of chromosome 1p and amplification of N-myc oncogene It is associated with the Beckwith-Wiedemann syndrome, Hirschsprung's disease and neurofibromatosisHemorrhage, calcification and necrosis are common macroscopic features 6. The following statements regarding normal prostate are true, EXCEPT:Denonvillier's fascia separates the prostate and seminal vesicles from the rectum Lipofuscin pigment helps differentiate seminal vesicle tissue from prostatic glands Large number of neuroendocrine cells are present in prostatic epitheliumSkeletal muscle of the urogenital diaphragm extends into the prostate in its most apical aspectAnterior fibromuscular stroma occupies approximately 1/3 of the prostate, contains very few glands and consists of smooth muscle and dense fibrous tissue 7. This subtype of prostatic carcinoma overall has a better prognosis than the usual acinar type:Small cell carcinomaAdenoid basal cell tumor (adenoid cystic tumor)Signet ring carcinoma Mucinous adenocarcinoma Ductal carcinoma 8. All of the following parameters are associated with adverse outcome in prostatic carcinoma, EXCEPT:Positive surgical marginsExtraprostatic extensionInvolvement of seminal vesicle Perineural invasion Nodal metastases 9. If seen on a prostate core biopsy this prostatic adenocarcinoma would be best graded as Gleason score =3 for 60%, Gleason score = 4 for 25%, and Gleason score = 5 for 15%. How would the case be scored overall?Gleason score 3 + 5 = 8/10 Gleason score 4 + 5 = 9/10 Gleason score 5 + 3 = 8/10 Gleason score 3 + 3 = 6/10 Gleason score 3 + 4 = 7/10 Loading...
