Karyorrhexis
Karyorrhexis of erythroid precursors is refined as a pyknotic nucleus with nuclear (destructive) fragmentation (an abnormal form of apoptosis) that results in cell death.
![Dyserythropoiesis - Karyorrhexis](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_9-1024x687.jpeg)
![Dyserythropoiesis - Karyorrhexis](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_10.jpeg)
![Dyserythropoiesis - Karyorrhexis](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_17-1024x682.jpeg)
Nuclear Budding
![Dyserythropoiesis - Nuclear Budding](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_12-1024x739.jpeg)
![](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_1.jpeg)
Mutlinucleation
![Dyserythropoiesis - Multinucleated erythorid precursor](https://www.pathmd.com/wp-content/uploads/2017/12/Dyserythropoiesis_2_16.jpeg)
Vacuolated Erythroid Precursors
![Vacuolated Erythroid Precursor](https://www.pathmd.com/wp-content/uploads/2017/12/BM_Zinc_Asp_10-1024x768.jpeg)
Ring Sideroblasts
![Ring Sideroblasts (Iron Stain)](https://www.pathmd.com/wp-content/uploads/2017/12/P8280015-e1513089007341-1024x737.jpg)
References
Zhou T, Kinney MC, Scott LM, Zinkel SS, Rebel VI. Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research. Blood. 2015;126: 1057–1068. doi:10.1182/blood-2015-01-624239
Swerdlow SH, Campo E, Harris, NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition). IARC: Lyon 2017