Sclerosing Adenosis (SA) is an increased density of duct-lobular acini, which characteristically are compressed in the central portion of the lesion with dense stroma/fibrosis. Sometimes these lesions can closely mimic an invasive ducatal carcinoma, immunohistochemistry is necessary to separate lesions.
SA is not a neoplastic process, but is associated with a 1.5-2X increased relative risk for breast carcinoma.
Breast lesions and risk of developing an invasive carcinoma
![Breast Cancer Risk Chart](https://www.pathmd.com/wordpress/wp-content/uploads/2017/10/Breast_Ca_Risk_Chart-1024x569.jpg)
References
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.