This is an aggressive lympho-proliferative disorder associated with Human T-Cell Leukemia Virus Type I (HTLV-1). Most patients present with widespread lymphadenopathy and peripheral blood involvement.
Immunophenotypic Expression Pattern
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Marker
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Comment
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Positive
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Positive
|
|
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Positive
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|
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Usually Negative
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Usually Positive
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|
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Usually negative (there are occasional CD8+/CD4= or CD8+/CD4+ cases)
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Strongly expressed in almost all cases.
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May stain some large transformed cells.
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Negative
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|
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TIA-1
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Negative
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Negative
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HTLV-1
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Positive. There is no IHC stain, but this is an important test that can be done on the peripheral blood.
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References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 281-84.