This is an “aggressive” leukemia/lymphoma disorder, which is almost always associated with EBV. Location of involvement can range from peripheral blood to bone marrow, spleen, and, liver. Any organ can be involved.
Immunophenotypic Expression Pattern
|
Marker
|
Comment
|
|
Positive
|
|
|
Surface negative. Cytoplasmic CD3ε positive.
|
|
|
Positive
|
|
|
TIA-1
|
Positive
|
|
Positive
|
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.