Immunophenotypic Expression Pattern
|
Marker
|
Comment
|
|
Negative, by definition.
|
|
|
Positive, should be strong and of equal intensity.
|
|
|
+/- more often positive than CD5
|
|
|
+/- more often positive than CD5
|
|
|
Usually Positive
|
|
|
-/+
|
|
|
+/-
|
|
|
Negative (rare +)
|
|
|
Negative
|
|
|
Often Positive
|
|
|
EBV (EBER)
|
Negative. If positive, it should raise concern of a classical Hodgkin lymphoma.
|
|
Often Positive
|
|
|
Perforin
|
Often Positive
|
|
TIA-1
|
Often Positive
|
|
Negative
|
|
|
Negative. If positive, then this should raise the possibility of classical Hodgkin lymphoma.
|
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 312-19.