PathMD Quizes, Renal Renal Neoplasms – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A 5 cm mass is removed from a 41 y/o female which is found to have areas of smooth muscle cells, blood vessels, and fat. Special stains for HMB-45 were positive. This lesion is associated with all of the following conditions EXCEPT:von Recklinghausen disease von Hippel-Lindau (VHL) syndrome Tuberous sclerosis Birt-Hogg-Dube syndrome 2. Which of the following is most helpful in differentiating chromophobe RCC from an oncocytoma:BinucleationPerinuclear halosPleomorphismGranular cytoplasm 3. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorNone of the aboveOncocytomaRenal Cell Carcinoma, Conventional Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Chromophobe 4. This tumor from the kidney illustrated in images below was negative for S-100 and desmin. In other areas of the tumor, RCC marker was focally positive. Which of the following is the best diagnosis? Renal Tumor Renal TumorMetastatic malignant melanoma RhabdomyosarcomaNone of the above LeiomyomaRCC, Fuhrman grade IV 5. The image below shows a renal tumor stained with Hale’s Colloidal Iron. The most likely diagnosis is: Renal Tumor Hale's Colloidal IronOncocytomaRCC, sarcomatoid type RCC, chromophobe type RCC, papillary type RCC, conventional type 6. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal Tumor Renal TumorWilm’s tumorRenal cell carcinoma, papillary typeRhabdomyosarcomaNone of the above Metanephric adenoma 7. A 30 y/o African American male whose mother has sickle cell disease, is found to have a renal mass by CT examination. Which of the following are the most likely histologic features of this mass:Tubular Mucinous Spindle cell RCC Clear cells with abundant cytoplasm, irregular nuclei, and a fine network of thin walled vessels surrounding nests of cells. Reticular / yolk sac-like pattern with focal areas having an adenoid-cystic pattern. Papillary cores filled with foamy macrophages admixed with other areas of tubular and solid architecture. The cytoplasm is acidophilic, and no clear cell component is identified. Tubulopapillary architecture of infiltrating cells some with a hobnail like appearance. Tumor cell nuclei are high grade. 8. An 18 y/o Caucasian male is found to have a renal tumor with clear cell RCC histology. It is important to perform cytogenetic analysis on this mass to look for involvement of which of the following chromosomes:Chromosome 11p13 None of the aboveChromosome 7Xp11.23p 9. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorNone of the aboveRenal Cell Carcinoma, ChromophobeRenal Cell Carcinoma, PapillaryOncocytomaRenal Cell Carcinoma, Conventional 10. According to the AJCC staging manual, all of the following affect the pathological staging of renal cell carcinoma EXCEPT:Fuhrman grade Extension into perinephric fat Renal vein involvement SizeExtension into renal sinus fat 11. An incidental renal lesion <1cm with papillary features and composed of predominantly clear cells is best classified as:Renal cell carcinoma, chromophil typePapillary carcinomaRenal cell carcinoma, NOSPapillary adenoma Renal cell carcinoma, clear cell type 12. Which of the following result in the highest stage for a renal cell carcinoma according to the 2002 AJCC staging manual:Tumor directly invades adrenal gland Tumor grossly invades the wall of the vena cava Tumor grossly extends into the vena cava above the diaphragmMetastasis to one single regional lymph nodeTumor invades beyond Gerota’s fascia 13. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorNone of the above Renal Cell Carcinoma, Chromophobe OncocytomaRenal Cell Carcinoma, Papillary Renal Cell Carcinoma, Conventional 14. A renal tumor has predominantly clear cells with the highest grade area containing cells with irregular nuclear border (size ~20m) and nucleoli visible from 10X. Many of the cells are noted to have eccentrically placed nuclei and eosinophilic cytoplasm. The best Fuhrman grade is:Fuhrman grade IFuhrman grade IIFuhrman grade VFuhrman grade IVFuhrman grade III Loading...
PathMD Quizes, Renal Renal Neoplasms – 01 October 29, 2017 peferguson Please go to Renal Neoplasms – 01 to view this test
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