CDX-2, Villin, and/or HepPar-1 may be early markers of intestinal metaplasia before goblet cells are readily identifiable. These markers may be helpful to identify intestinal metaplasia in the setting of an endoscopic exam c/w Barrett’s esophagus, but the biopsy fails to demonstrate goblet cells.
p53 usually shows strong diffuse positivity in high-grade dysplasia in Barrett’s esophagus. Weak and focal positivity may be seen in biopsies ranging from reactive changes to low-grade dysplasia.
