Breast – Collagenous Spherulosis

Collagenous Spherulosis is an uncommon incidental benign finding, which can be confused with other pathologies such as DCIS, carcinoma, and adenoid cystic carcinoma of the breast.

The lesions are characterized by central mucin with epithelial cells (luminal and myoepithelial) radially arranged at the periphery.

Photomicrographs

Breast - Collagenous Spherulosis — Breast – Collagenous Spherulosis

References

Resetkova, E., et. al. “Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature.”. Am J Surg Pathol. 30 (1):207. Jan 2006. doi:10.1097/01.pas.0000179237.91515.81