Clear cell renal cell carcinoma is the most common malignant renal neoplasm (70–80% of renal cancers). These tumors are associated with a deletion in chromosomes 3p. The von Hippel-Lindau (VHL) gene lies in the deleted region, and is thought to act as a tumor suppressor gene in both the sporadic and familial forms of this tumor. In difficult cases to classify histologically, knowledge of genetic abnormalities within the tumor can be important to sub-classifying renal carcinomas.
Category Archives: Renal
Papillary Renal Cell Carcinoma
Papillary renal cell carcinoma represents approximately 10–15% renal neoplasms, and the name describes its characteristic papillary histology. From a molecular standpoint, tumors are associated with trisomy 7, trisomy 17, and loss of chromosome Y (trisomy 7 in the familial form). In contrast to clear cell renal cell carcinoma these tumors are NOT associated with 3p deletions.
Xp11.2 Translocation Associated Renal Cell Carcinoma
RCC with Xp11.2 translocation is a unique renal neoplasm more commonly found in younger patients characterized by a translocation of TFE3 gene located on chromosome Xp11.2. This results in over-expression of the transcription factor, which can be visualized by IHC staining with Xp11.2.
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Chromophobe Renal Cell Carcinoma
Renal Neoplasms
Renal Neoplasms – Malignant (2004 WHO Classification)
- Clear Cell Renal Cell Carcinoma (70%)
- Papillary Renal Cell Carcinoma (10%)
- Chromophobe Renal Cell Carcinoma (5%)
- Hereditary Cancer Syndromes (5%)
- Multilocular Cystic Renal Cell Carcinoma (<1%)
- Xp11.2 Translocation Renal Cell Carcinoma (<1%)
- Collecting Duct Carcinoma (<1%)
- Mucinous Tubular & Spindle Cell Carcinoma (<1%)
- Nephroblastoma-Related Renal Cell Carcinoma (<1%)
- Medullary (Renal) Carcinoma
- Unclassified Lesions (4%)