PathMD Quizes, GU Pathology GU Pathology – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. 63 year old male with a history of bilateral ocular MALT lymphoma treated with radiation therapy. He now presents with diffuse pelvic infiltrative process involving the bladder, prostate, seminal vesicles, rectosigmoid, distal ureters, and adjacent muscles. Bladder and prostate biopsies were performed. Based on histology, the process is most consistent with:Invasive transitional cell carcinoma (urothelial neoplasm) Recurrent MALT lymphoma Idiopathic retroperitoneal fibrosis High-grade lymphoma High grade prostatic adenocarcinoma 2. The following statements regarding normal prostate are true, EXCEPT:Denonvillier's fascia separates the prostate and seminal vesicles from the rectum Large number of neuroendocrine cells are present in prostatic epitheliumSkeletal muscle of the urogenital diaphragm extends into the prostate in its most apical aspectAnterior fibromuscular stroma occupies approximately 1/3 of the prostate, contains very few glands and consists of smooth muscle and dense fibrous tissue Lipofuscin pigment helps differentiate seminal vesicle tissue from prostatic glands 3. If seen on a prostate core biopsy this prostatic adenocarcinoma would be best graded as Gleason score =3 for 60%, Gleason score = 4 for 25%, and Gleason score = 5 for 15%. How would the case be scored overall?Gleason score 3 + 4 = 7/10 Gleason score 3 + 5 = 8/10 Gleason score 5 + 3 = 8/10 Gleason score 4 + 5 = 9/10 Gleason score 3 + 3 = 6/10 4. All of the statements concerning a fibroepithelial polyp of the bladder are true, EXCEPT:This lesion has no malignant potential It represents a mesenchymal tumor There is a female predominanceIt occurs most commonly at the ureteropelvic junction and upper ureter It is mostly found in children and young adults 5. A 3 year old boy presents with a large abdominal mass consistent with neuroblastoma. All of the following statements regarding this condition are correct, EXCEPT:Histologically, the most prominent feature is presence of Homer Wright rosettesIt is associated with the Beckwith-Wiedemann syndrome, Hirschsprung's disease and neurofibromatosisOver 80% are detected in children under the age of 4 Two characteristic genetic events are loss of a distal region of chromosome 1p and amplification of N-myc oncogene Hemorrhage, calcification and necrosis are common macroscopic features 6. A 42 yo female presented with hypertension, Cushing's syndrome and virilization. A representative section from her resection specimen is consistent with an adrenal cortical carcinoma. All of the following features are part of diagnostic criteria for this tumor EXCEPT:Tumor weightVascular invasionTumor necrosis Cellular pleomorphismDiffuse growth pattern 7. This subtype of prostatic carcinoma overall has a better prognosis than the usual acinar type:Mucinous adenocarcinoma Small cell carcinomaSignet ring carcinoma Ductal carcinomaAdenoid basal cell tumor (adenoid cystic tumor) 8. All of the following parameters are associated with adverse outcome in prostatic carcinoma, EXCEPT:Nodal metastases Involvement of seminal vesicle Perineural invasion Extraprostatic extensionPositive surgical margins 9. All of the following statements are correct regarding this kidney neoplasm, EXCEPT: GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5It is associated with Beckwith-Wiedemann and Denys-Drash syndromes It always has three components: undifferentiated blastema, mesenchymal tissue and epithelial tissueLesions are divided into favorable and unfavorable histology groups based on the degree of anaplasia Staging is the most important prognostic determinator 90% of the cases occur before the age of 6 Loading...
