Chromophobe Renal Cell Carcinoma

Chromophobe renal cell carcinoma is not uncommon subtype characterized by pale eosinophilic cytoplasm, rigid cell membranes (vegetable cell-like), and perinuclear halos. These cases constitute approximately 5% of renal cell cancers. These tumors are thought to arise from the intercalated cells of the collecting ducts, and have a relatively good prognosis compared to conventional renal cell carcinomas. Many experts believe that chromophobe renal cell carcinoma and oncocytoma represented to ends of the spectrum. Interestingly, oncocytomas share some molecular abnormalities with chromophobe renal cell carcinomas.

Immunohistochemistry


Photomicrographs
Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma
CD117 - Chromophobe Renal Cell Carcinoma
CD117 expression in a Chromophobe Renal Cell Carcinoma
E-Cadherin - Chromophobe Renal Cell Carcinoma
E-Cadherin expression in Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma - Hales Colloidal Iron
Chromophobe Renal Cell Carcinoma – Hales Colloidal Iron
References

Robbins and Cotran Pathologic Basis of Disease.  V Kumar, et al. 9th Edition. Elsevier Saunders. 2015.

Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 2010;135: 92–109. Available: http://www.archivesofpathology.org/doi/pdf/10.1043/2010-0478-RAR.1