CHL Immunohistochemical Features:
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Positive in the malignant cells in almost all cases. Membrane staining with Golgi area positivity.
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Positive in the malignant cells in a majority of cases (75-85%). The staining pattern is similar to CD30. It should be noted that there is a lot a variability lab to lab in the performance of the antibody.
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Usually negative
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Dim expression in the lymphoma cells in >90% of the cases. Helpful in differentiating cases from anapestic large cell lymphoma, which may be CD45 negative.
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Usually negative, but may have dim variable subset expression in up to 20% of cases.
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Rarely positive in the lymphoma cells.
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Usually positive and usually intense.
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EBV
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Variable
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Rarely positive and usually weak if positive.
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OCT-2
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Negative in 90% of cases.
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Negative in 90% of cases.
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Negative or dim expression
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Negative.
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References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.
Robbins and Cotran Pathologic Basis of Disease. V Kumar, et al. 9th Edition. Elsevier Saunders. 2015.
WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. SH Swerdlow, et al. International Agency for Research on Cancer. Lyon, 2008.