EBV Positive DLBCL of the Elderly

EBV+ DLBCL of the Elderly is an EBV expressing DLBCL in patients >50 years of age.  Other lymphomas, which may express EBV, are excluded from this categorization.  Most cases (70%) are extra nodal, while the remaining 30% have lymph node disease only.

Characteristic Immunophenotype
Marker
Comment
Negative
Positive.  Cases with a plasmablastic differentiation may be negative.
Positive
EBV
LMP-1 is expressed in 94% of cases.  EBNA-2 expression is seen in ~28% of cases.
EBER
Positive
Variable
Negative
Usually Negative
Usually Negative
References
Wong, HH. et. al. “Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly.” Leuk Lymhpoma 2009. Mar;50(3):335-40.
 
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 243-4.