This is a rare disorder of clonal EBV-infected T-cells, which contain an activated cytotoxic phenotype. There is some clinicopathologic overlap with aggressive NK-cell leukemia. May be associated with acute or chronic EBV infection.
Immunophenotypic Expression Pattern
|
Marker
|
Comment
|
|
Positive
|
|
|
Positive
|
|
|
Negative
|
|
|
TIA-1
|
Positive
|
|
Positivity is associated with chronic active EBV infection.
|
|
|
Positivity is associated with acute primary EBV infection.
|
|
|
EBV (EBER)
|
Positive
|
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.