European Group for the Immunological Characterization of Leukemias (EGIL) algorithm for biphenotypic blasts.
|
Points
|
B
|
T
|
Myeloid
|
|
2
|
cyCD79a
|
CD3 (cy or sm)
|
MPO
|
|
|
cyCD22
|
TCR-αβ
|
|
|
|
cyIgM
|
TCR-γδ
|
|
|
1
|
CD19
|
CD2
|
CD117
|
|
|
CD20
|
CD5
|
CD13
|
|
|
CD10
|
CD8
|
CD33
|
|
|
|
CD10
|
CDw65
|
|
0.5
|
TdT
|
TdT
|
CD14
|
|
|
CD24
|
CD7
|
CD15
|
|
|
|
CD1a
|
CD64
|
Biphenotypic leukemia is defined as a score >2 in 2 lineage columns.
WHO 2008/2016 Criteria for Mixed-Phenotype Blasts
Mixed Phenotypic Acute Leukemias (MPAL)
References
Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias: European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9(10):1783–1786