PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A specimen being prepared for electron microscopy should be fixed in:Bouin’sB5GluteraldehydeZinc formalin Mercury based fixative 2. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:EpendymomaLymphomaSchwannomaCarcinomaMeningioma 3. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?CD45CD138Hale’s colloidal ironSynaptophysinS-100 4. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2Granular Cell Tumor MelanomaAdenocarcinomaPlasmacytomaSchwannoma 5. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:Thyroid follicular carcinoma Breast adenocarcinoma GI adenocarcinoma MesotheliomaProstate carcinoma 6. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5Renal Cell Carcinoma, clear cell typeOncocytomaGranular Cell Tumor MelanomaRenal Cell Carcinoma, chromophobe type 7. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1SchwannomaSquamous Cell Carcinoma AdenocarcinomaMesotheliomaMelanoma 8. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show abundant rough endoplasmic reticulum EM will show abundant mitochondria EM will show cytoplasmic microvilli EM will show numerous premelanosomes EM will show numerous lysosomes 9. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3MelanomaSquamous Cell Carcinoma MesotheliomaAdenocarcinomaSchwannoma 10. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:Prostate carcinoma Pulmonary adenocarcinomaBreast adenocarcinoma MesotheliomaThyroid follicular carcinoma 11. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:SchwannomaCarcinomaChoroid plexus tumorAstrocytomaEpendymoma 12. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4SchwannomaLymphomaSquamous Cell Carcinoma AdenocarcinomaMeningioma 13. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?Papillary ependymoma Clear cell sarcomaNeurocytomaMedulloblastomaAlveolar soft part sarcoma Loading...