PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2PlasmacytomaMelanomaAdenocarcinomaSchwannomaGranular Cell Tumor 2. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:MesotheliomaThyroid follicular carcinoma Breast adenocarcinoma Prostate carcinoma Pulmonary adenocarcinoma 3. A specimen being prepared for electron microscopy should be fixed in:Zinc formalin Bouin’sMercury based fixativeGluteraldehydeB5 4. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:Prostate carcinoma Breast adenocarcinoma MesotheliomaGI adenocarcinoma Thyroid follicular carcinoma 5. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3Squamous Cell Carcinoma MesotheliomaMelanomaSchwannomaAdenocarcinoma 6. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?NeurocytomaMedulloblastomaAlveolar soft part sarcoma Clear cell sarcomaPapillary ependymoma 7. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4SchwannomaMeningiomaLymphomaSquamous Cell Carcinoma Adenocarcinoma 8. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:CarcinomaLymphomaSchwannomaEpendymomaMeningioma 9. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1AdenocarcinomaMelanomaSquamous Cell Carcinoma MesotheliomaSchwannoma 10. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?CD138CD45SynaptophysinS-100 Hale’s colloidal iron 11. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:CarcinomaSchwannomaEpendymomaAstrocytomaChoroid plexus tumor 12. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show cytoplasmic microvilli EM will show abundant mitochondria EM will show numerous lysosomesEM will show abundant rough endoplasmic reticulum EM will show numerous premelanosomes 13. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5Renal Cell Carcinoma, chromophobe type Renal Cell Carcinoma, clear cell typeMelanomaOncocytomaGranular Cell Tumor Loading...