Immunophenotypic Expression Profile
|
Marker
|
Comment
|
|
Positive
|
|
|
Usually Negative (Surface negative, cytoplasmic epsilon positive)
|
|
|
CD3-ε
|
Positive (cytoplasmic)
|
|
Negative
|
|
|
Negative
|
|
|
Positive
|
|
|
Negative (a few cases are positive)
|
|
|
Positive
|
|
|
Positive
|
|
|
Positive. Not specific for extra nodal NK/T-cell lymphoma, and may be expressed in other T-cell lymphomas.
|
|
|
EBV (EBER)
|
Positive. Negative cases should be re-evaluated very closely.
|
|
Positive
|
|
|
Perforin
|
Positive
|
|
TIA-1
|
Positive
|
|
Negative
|
|
|
Negative
|
|
|
Negative
|
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 287-88.