GIST Immunohistochemistry Expression
|
IHC Stain
|
Percentage
|
|
~95%
|
|
|
>95%
|
|
|
80% gastric
50% Sm. Int.
95% Esoph.
95% Rectum
|
|
|
Rare
|
|
|
<1%
|
|
|
~5%
|
|
|
SMA
|
~35%
|
Liegl-Atzwanger, et. al. Virchows Arch, Feb. 18, 2010.
Mod Path (2008)21,46-53.
GIST Immunohistochemial Diagnostic Panel
|
IHC Stain
|
Comment
|
|
>95% sensitivity for GIST
|
|
|
Often + in GIST, less specific
|
|
|
Expressed in Schwannomas, which may have similar morphology to spindle cell GISTs
|
|
|
Expressed in leiomyoma/leiomyosarcoma. Rare GISTs will show expression
|
It is important to interpret these stains as part of a panel to maximize specificity of diagnosis.