PathMD Quizes, Gynecological Pathology Gynecological Pathology – 03 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A 65-year-old female presents to her gynecologist complaining of postmenopausal bleeding. Ultrasound showed an enlarged uterus, and a hysterectomy was performed. Representative images from the uterine corpus are shown. Based on the morphologic findings, which of the following is the best diagnosis? Gynecological Pathology - Part 3, Question #2 Gynecological Pathology - Part 3, Question #2 Gynecological Pathology - Part 3, Question #2 Gynecological Pathology - Part 3, Question #2Papillary syncytial metaplasia Mixed endometrial and high-grade serous adenocarcinomaHigh-grade serous adenocarcinoma Squamous metaplasia 2. A 36 y/o woman is found to have an enlarged uterus, which measures approximately 8 weeks. Serum pregnancy test is negative, and the patient also complains of irregular menstrual bleeding. A total abdominal hysterectomy performed, and the morphologic findings are shown in the images for this case. Based on the findings, what is the best diagnosis? Gynecological Pathology - Part 3, Question #1 Gynecological Pathology - Part 3, Question #1 Gynecological Pathology - Part 3, Question #1Adenomatoid tumorLeiomyosarcomaLow-grade stromal sarcoma Leiomyoma 3. What is the current recommendation from the CAP/ASCO panel for the minimum criteria of 3+ Her-2/neu positivity on IHC tissue stained sections (i.e. not FISH) in breast cancer cases?Uniform intense membranous staining in at least 75% of tumor cells Uniform intense membranous staining in at least 50% of tumor cells Uniform intense membranous staining in at least 30% of tumor cells Uniform intense membranous staining in at least 10% of tumor cells Uniform intense membranous staining in at least 1% of tumor cells 4. A 70-year-old woman presents to her primary care physician with vaginal bleeding. Her uterus was noted to be slightly enlarged on ultrasound examination. A total abdominal hysterectomy was performed, and representative images of the endometrium are shown. Based on the morphologic findings, which of the following is the best diagnosis? Gynecological Pathology - Part 3, Question #4 Gynecological Pathology - Part 3, Question #4 Gynecological Pathology - Part 3, Question #4Yolk sac tumorHigh-grade serous carcinomaEndometrioid carcinoma, grade 3Clear cell carcinoma 5. A 45-year-old female presents with an adnexal tumor. A unilateral oophorectomy is performed, and representative images of a portion of the ovary are shown. Based on the morphologic findings pages for this case, what is the most common diagnosis that can be associated with this lesion in approximately one third of cases? Gynecological Pathology - Part 3, Question #5 Gynecological Pathology - Part 3, Question #5 Gynecological Pathology - Part 3, Question #5Small cell carcinoma Mucinous cystic neoplasm Serous cystic neoplasmSquamous cell carcinomaTransitional cell carcinoma 6. A 67-year-old female is found to have an ovarian mass. A total abdominal hysterectomy with bilateral oophorectomy was performed. A mass limited to the ovary was present, and representative images are shown. Based on the findings, what is the best diagnosis? Gynecological Pathology - Part 3, Question #6 Gynecological Pathology - Part 3, Question #6 Gynecological Pathology - Part 3, Question #6Endometrioid carcinoma (FIGO grade 3)Small cell carcinoma Transitional cell carcinoma High grade serous carcinoma 7. Cervical carcinoma that is clinically visible and confined to the cervix would be classified as what?pT4pT1pT2apT3pT2b 8. An endometrial stromal sarcoma is found to be confined to the uterus and invades the outer one half of the myometrium. What is the pathologic stage (pT)?pT2apT1bpT2bpT1cpT1a 9. A primary ovarian serious carcinoma is present in the right and left ovaries. A 3 cm omental implant is also present. What is the pathologic stage (pT)?pT2bpT3bpT2cpT3cpT1c 10. A 36-year-old woman presents her gynecologist with irregular menstrual bleeding. An endometrial biopsy was performed two weeks later, with representative images shown. Based on morphology, which of the following is the best diagnosis? Gynecological Pathology - Part 3, Question #3 Gynecological Pathology - Part 3, Question #3Secretory carcinoma Low-grade secretory endometrial carcinomaNormal secretory endometrium Papillary syncytial metaplasia Loading...