PathMD Quizes, Hematopathology Hematopathology – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following characteristics is the most important defining feature of AML-M2?< 3% myeloperoxidase positive myeloblasts 20% of more promyelocytes maturation of at least 10% of non-erythroid cells 50% of more erythroid precursors 20-80% immature monocytes 2. AML-M3 is characterized by?50% of more erythroid precursors < 3% myeloperoxidase positive myeloblasts 20% of more promyelocytes 20-80% immature monocytes >90% myeloblasts of non-erythroid cells 3. A 50-year-old male presents with mild splenomegaly and circulating atypical lymphocytes. Flow cytometry identifies a CD20 positive, CD5 and CD10 negative kappa restricted lymphoid population. Based on the morphologic and flow cytometry findings, which of the following is the best diagnosis? Hematopathology - Part 2, Case #6 Hematopathology - Part 2, Case #6 Hematopathology - Part 2, Case #6Mantle cell lymphoma Splenic marginal zone lymphoma Circulating follicular lymphoma Chronic lymphocytic leukemia/lymphoma Extranodal marginal zone lymphoma 4. Which of the following characteristics is the most important defining feature of AML-M1?50% of more erythroid precursors >90% myeloblasts of non-erythroid cells 20-80% immature monocytes < 3% myeloperoxidase positive myeloblasts 20% of more promyelocytes 5. A cervical lymph node is biopsied from a 25 y/o man. Representative histology from the lymph node is shown. Based on the findings, what is the expected immunohistochemistry profile? Hematopathology - Part 2, Case #2 Hematopathology - Part 2, Case #2 Hematopathology - Part 2, Case #2CD15 +, CD20 +, CD 30 +, CD45 = CD15 +, CD20 +, CD 30 =, CD45 = CD15 +, CD20 +, CD 30 +, CD45 + CD15 +, CD20 =, CD 30 +, CD45 = CD15 +, CD20 =, CD 30 +, CD45 + 6. A 40 y/o man presents with isolated inguinal lymphadenopathy. An excisional biopsy is performed. Representative sections and special stains are shown. Based on the findings, what is the best diagnosis? Hematopathology - Part 2, Case #3 Hematopathology - Part 2, Case #3 Hematopathology - Part 2, Case #3. BCL-2 IHC stain.Follicular lymphomaMantle cell lymphoma Reactive follicular hyperplasia Burkitt lymphoma Cat-scratch lymphadenitis 7. A 50 y/o male presents with nasal obstruction. A biopsy is performed and representative sections are shown. The cells of interest are positive for CD56 and EBV by in situ hybridization (EBER). Based on these findings, what is the best diagnosis? Hematopathology - Part 2, Case #1 Hematopathology - Part 2, Case #1 Hematopathology - Part 2, Case #1Wegner’s granulomatosisT-cell lymphoma, unspecified T-cell ALLExtranodal NK/T-cell lymphomaAngio-immunoblastic T-cell lymphoma 8. A soft tissue mass is found in the breast of a 45 y/o female that was thought to probably represent breast carcinoma. Representative images are shown. The histiocytic cells are positive for S-100 and negative for CD1a. Based on the findings, what is the best diagnosis? Hematopathology - Part 2, Case #4 Hematopathology - Part 2, Case #4Rosai-Dorfman disease Histiocytosis X Malignant melanoma Langerhan’s cell histiocytosisPlasmacytoma 9. Which of the following characteristics is the most important defining feature of AML-M0?20% of more promyelocytes 20-80% immature monocytes 50% of more erythroid precursors >90% myeloblasts of non-erythroid cells < 3% myeloperoxidase positive myeloblasts 10. Based on the morphologic findings of the peripheral blood smear for this question, which of the following is the best diagnosis? Hematopathology - Part 2, Case #5 Hematopathology - Part 2, Case #5 Hematopathology - Part 2, Case #5Hemoglobin SCHemoglobin SS Hereditary SpherocytosisAlpha ThalassemiaLiver Disease Loading...
