PathMD Quizes, Hematopathology Hematopathology – 05 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A patient with a history of acute leukemia undergoes a bone marrow aspiration. Part of the specimen is sent for cytogenetic analysis. Results of the karyotype are shown in the image for this case. Based on the findings (which are highlighted by red arrows), what is the best diagnosis? Hematopathology - Part 5, Case #5AML-M4EoAML-M2 AML-M5aALLAML-M3 2. All of the following are true with respect to MALT/marginal zone lymphomas EXCEPT:t(11;18) is associated with lower response to H. pylori therapy Trisomy 3 in a majority of MALT cases None of the answers are incorrectNot present in primary large B-cell gastric lymphoma Are typically indolent disease processes 3. A patient presents with an elevated WBC count, and flow cytometry is performed. Based on the dot plots shown on the website images for this case, what is the best diagnosis? Hematopathology - Part 5, Case #1 Hematopathology - Part 5, Case #1 Hematopathology - Part 5, Case #1 Hematopathology - Part 5, Case #1 Hematopathology - Part 5, Case #1Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaMantle cell lymphoma Peripheralized Marginal Zone Lymphoma T-cell ALL B-cell ALL 4. A 36 year old Hispanic male with a CD4 count of 20 presents to the emergency department complaining of chronic headaches for several months. A routine CBC showed pancytopenia, and a bone marrow biopsy was performed. Based on the findings, what is the most likely diagnosis? Hematopathology - Part 5, Case #4 Hematopathology - Part 5, Case #4 Hematopathology - Part 5, Case #4 Hematopathology - Part 5, Case #4. GMS stain.Mycobacterium avium BlastomycosisHistoplasmosisCryptococcusCoccidiomycosis 5. Mantle Cell Lymphoma is associated with which of the following:t(2;5)t(14;18)t(8;14)t(11;14)t(11;18) 6. A 40 year old woman presents with an elevated WBC count (25K) with abnormal immature cells noted by the hematology technologist (see case images). Flow cytometry demonstrated the cells to be positive for CD13 and CD33 and negative for CD34 and HLA-DR. What is the best diagnosis? Hematopathology - Part 5, Case #3 Hematopathology - Part 5, Case #3 Hematopathology - Part 5, Case #3 Hematopathology - Part 5, Case #3. Myeloperoxidase (MPO).AML-M2APLAML-M0B-ALLAML-M4 7. Which of the following are associated with a worse prognosis in CLL/SLL:Trisomy 12Del 13q14 All of the answers are correct CD38 expression on flow cytometry and trisomy 12 8. Which of the following chromosomal abnormalities is commonly found in multiple myeloma:+5 del 8 del 14 13q14 or monosomy 13 +3 9. A 12 year old boy presents with a WBC of 233K. The bone marrow aspirate with a myeloperoxidase stain are shown. Flow cytometry demonstrated CD19 positivity. What is the best diagnosis? Hematopathology - Part 5, Case #6 Hematopathology - Part 5, Case #6 Hematopathology - Part 5, Case #6. Myeloperoxidase (MPO).APLPre T-ALL Pre B-ALL AML-M2 with t(8;21) AML-M4 10. A patient presents with an elevated WBC count, and flow cytometry is performed. Based on the dot plots shown the website images for this case, what is the best diagnosis? Hematopathology - Part 5, Case #2 Hematopathology - Part 5, Case #2 Hematopathology - Part 5, Case #2 Hematopathology - Part 5, Case #2 Hematopathology - Part 5, Case #2 Hematopathology - Part 5, Case #2Mantle cell lymphoma Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaPeripheralized Marginal Zone LymphomaT-cell ALL B-cell ALL Loading...