PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Thymic aplasiaCleft palate Deletions on chromosome 11q22 Cardiac abnormalitiesHypocalcemia 2. Which one of the following statements regarding complement C3 is incorrect?Part of the membrane attack complex (MAC) Deficiencies are associated with increased risk of meningococcal infection Enzymatic cleavage yields an anaphylatoxin and an opsonin Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisPredominantly produced by the hepatocyte 3. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1None are correctPeak V is consistent with a polyclonal gammopathyThis pattern is consistent with nephrotic syndromeHaptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode 4. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area V is the site of pepsin cleavageArea II represents the carboxy terminusArea III represents the constant domain Area IV is a crystallizable fragment Area III has bivalent binding capacity 5. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are pathognomonic for MS Oligoclonal bands are found in the beta-2 regionA serum specimen must be run concurrently for comparisonSilver staining is more rapid, but less sensitive than Coomassie BlueTypically performed by SDS-PAGE 6. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Anti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionLymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA) 7. The HLA gene is present at which chromosomal location?6q6p 3q3p22q 8. Which disease-hypersensitivity type association is incorrect?Goodpasture syndrome -- antibody-mediated (type II) Bee sting allergy – immediate (type I)Systemic lupus erythematosus -- immune complex-mediated (type III) Serum sickness – antibody-mediated (type II)Transplant rejection – cell-mediated (type IV) 9. Which one of the following statements best describes rheumatoid factor?The test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIt is an antibody against cellular DNAIgA rheumatoid factor is associated with less severe diseaseIt is an antibody against the Fab portion of IgGTest methodology is typically nephelometry or latex immunofixation 10. Which one of the following disease-HLA associations is incorrect?Goodpasture’s disease – B35Sjogren syndrome – DR3Rheumatoid arthritis – DR4Type I diabetes mellitus – DR3, DR4Ankylosing spondylitis – B27 11. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaAll of the aboveI and II onlyI, II, IIII onlyI, II, IV 12. Which one of the following statements regarding IgD is false?Does not bind to cells through its Fc region Does not cross the placenta About 1% of all serum immunoglobulins Binds complement 13. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, II, IVI, III, IVAll of the above II, III, IVI, II, III 14. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1 inhibitorC1C4properdinC3 convertase Loading...
