PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area II represents the carboxy terminusArea III represents the constant domain Area V is the site of pepsin cleavageArea III has bivalent binding capacityArea IV is a crystallizable fragment 2. The HLA gene is present at which chromosomal location?3q3p22q6p 6q 3. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Cardiac abnormalitiesThymic aplasiaCleft palate Hypocalcemia Deletions on chromosome 11q22 4. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Peak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromeNone are correctHaptoglobin is normally a component of peak IIPeak V is consistent with a polyclonal gammopathy 5. Which one of the following statements best describes rheumatoid factor?Test methodology is typically nephelometry or latex immunofixationIt is an antibody against the Fab portion of IgGIt is an antibody against cellular DNAIgA rheumatoid factor is associated with less severe diseaseThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive value 6. Which one of the following disease-HLA associations is incorrect?Type I diabetes mellitus – DR3, DR4Ankylosing spondylitis – B27Goodpasture’s disease – B35Sjogren syndrome – DR3Rheumatoid arthritis – DR4 7. Which one of the following statements regarding complement C3 is incorrect?Part of the membrane attack complex (MAC) Predominantly produced by the hepatocyteElevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisEnzymatic cleavage yields an anaphylatoxin and an opsonin Deficiencies are associated with increased risk of meningococcal infection 8. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI, II, IVI onlyI, II, IIII and II onlyAll of the above 9. Which one of the following statements regarding IgD is false?Does not cross the placenta About 1% of all serum immunoglobulins Binds complement Does not bind to cells through its Fc region 10. Which disease-hypersensitivity type association is incorrect?Serum sickness – antibody-mediated (type II)Goodpasture syndrome -- antibody-mediated (type II) Systemic lupus erythematosus -- immune complex-mediated (type III) Transplant rejection – cell-mediated (type IV) Bee sting allergy – immediate (type I) 11. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, II, III All of the above I, II, IVII, III, IVI, III, IV 12. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1 inhibitorC1C3 convertaseC4properdin 13. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are found in the beta-2 regionA serum specimen must be run concurrently for comparisonTypically performed by SDS-PAGE Oligoclonal bands are pathognomonic for MS Silver staining is more rapid, but less sensitive than Coomassie Blue 14. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesAnti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infection Loading...
