PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following statements regarding IgD is false?Does not cross the placenta About 1% of all serum immunoglobulins Binds complement Does not bind to cells through its Fc region 2. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)Anti-CMV IgG present in the patient’s serum confirms acute CMV infection Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesIgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infection 3. Which one of the following statements regarding complement C3 is incorrect?Predominantly produced by the hepatocytePart of the membrane attack complex (MAC) Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisEnzymatic cleavage yields an anaphylatoxin and an opsonin Deficiencies are associated with increased risk of meningococcal infection 4. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI and II onlyAll of the aboveI onlyI, II, IIII, II, IV 5. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1 inhibitorC4C1properdinC3 convertase 6. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are found in the beta-2 regionA serum specimen must be run concurrently for comparisonOligoclonal bands are pathognomonic for MS Silver staining is more rapid, but less sensitive than Coomassie BlueTypically performed by SDS-PAGE 7. Which one of the following disease-HLA associations is incorrect?Rheumatoid arthritis – DR4Sjogren syndrome – DR3Ankylosing spondylitis – B27Goodpasture’s disease – B35Type I diabetes mellitus – DR3, DR4 8. Which disease-hypersensitivity type association is incorrect?Goodpasture syndrome -- antibody-mediated (type II) Serum sickness – antibody-mediated (type II)Systemic lupus erythematosus -- immune complex-mediated (type III) Bee sting allergy – immediate (type I)Transplant rejection – cell-mediated (type IV) 9. The HLA gene is present at which chromosomal location?6p 6q22q3q3p 10. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Cleft palate Thymic aplasiaCardiac abnormalitiesDeletions on chromosome 11q22 Hypocalcemia 11. Which one of the following statements best describes rheumatoid factor?It is an antibody against the Fab portion of IgGIt is an antibody against cellular DNATest methodology is typically nephelometry or latex immunofixationThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIgA rheumatoid factor is associated with less severe disease 12. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area III represents the constant domain Area II represents the carboxy terminusArea IV is a crystallizable fragment Area III has bivalent binding capacityArea V is the site of pepsin cleavage 13. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsAll of the above I, III, IVI, II, IVI, II, III II, III, IV 14. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Haptoglobin is normally a component of peak IIThis pattern is consistent with nephrotic syndromePeak V is consistent with a polyclonal gammopathyPeak I is the closest peak to the cathode None are correct Loading...
