The B-cell population is predominately confined to the lumen of blood vessels. The IHC immunophenotype may be similar to other DLBCLs and may have either a germinal center or non-germinal center immunophenotype. There are several important characteristics.
Immunophenotypic Expression Characteristics
|
Marker
|
Comment
|
|
Negative (pan T-cell marker)
|
|
|
Positive
|
|
|
Co-expression may be seen on ~38% of the lymphoma cells.
|
|
|
Co-expression may be seen on ~13% of the lymphoma cells.
|
|
|
Variable. Usually positive in CD10 negative cases.
|
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.