Organ Systems, Breast

Invasive Lobular Carcinoma

General
  • Loss of E-Cadherin (CDH1 gene) expression
  • Minimal desmoplasia and can be difficult to identify grossly (clear margins may be difficult to achieve)
  • Single file infiltrating cells

Photomicrographs
Breast - Invasive Lobular Carcinoma
Breast – Invasive Lobular Carcinoma
Breast - Invasive Lobular Carcinoma
Breast – Invasive Lobular Carcinoma
Breast - Invasive Lobular Carcinoma
Breast – Invasive Lobular Carcinoma
References

Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.