1. What is the most common malignancy diagnosed each year in the world?

2. All of the following are characteristic of Horner syndrome EXCEPT:

3. Which if the following lung tumor is most likely to be located in the periphery?

4. As part of the manifestation of paraneoplastic syndromes, PTH-related peptide is most commonly associated with what lung carcinoma subtype?

5. What is the relative risk of developing lung cancer in an individual with asbestos exposure who also smokes?

6. A 4 cm tumor fromt the left upper lob is removed from a 70 year old male with a 70 pack-year history of smoking (still active). Morphology revealed large cells with prominent nucleoli and frequent mitosis. Gland formation, mucin production, intercellular bridges, and squamous pearls were NOT identified in the tumor. Immunohistochemistry was performed and showed no expression of TTF-1, Napsin A, p63, or CK5. Dim synaptophysin expression was present in a majority of tumor cells with strong diffuse expression of CD57. Chromogranin A was negative. What is the best classification of the lung tumor?