PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is correct regarding the central nervous system tumors?Supratentorial tumors are common in children Meningioma is the most common primary brain tumor The annual incidence is 2/100,000 for intracranial tumors Hematogenous spread is common in high grade tumors due to vascular proliferation Biologic behavior does not necessarily correlate with histology 2. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4Is a remote infarct with hemorrhagic component An organized abscess cavity Is an acute hemorrhage Is a remote intraparenchymal hematoma secondary to traumaIs encephalomalacia due to trauma 3. Which of the following cell types originate outside the central nervous system?OligodendrogliocytesEpendymocytesMicrogliocytesAstrocytesNeurons of the dentate gyrus 4. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14This is an undifferentiated tumor, although neuronal and glial markers can be expressedLosses of 22p is the most common genetic alterationIt has a high propensity to infiltrate throughout the brain parenchymaThis is a highly malignant tumor with 5-year survival rate of less than 10%The most common location is the pineal region of young adults 5. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Is the result of chronic methanol intoxication Predominantly affects granule cell layerCan lead to cerebellar dysfunction in about 20% of casesIs reversible with intensive therapyIs the result of an acute intoxication 6. Based on this image, this process: Neuropathology - Part 1, Question #7Is difficult to suspect due to ill-defined clinical picture Is primarily sporadicIs a specific form of viral encephalopathy Evolves within a span of decades, with eventual deathIs highly contagious among medical personnel 7. Which of the following is true regarding acute neuronal injury?Eosinophilic neuronal necrosis is the earliest light microscopic signIt represents the typical injury pattern associated with toxic-metabolic insultsIt can be reversible if detected by brain biopsy Healing neurons can be identified as chromatolyticRed neurons can be seen as early as 2 hours after injury 8. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Requires electron microscopic examination for definitive diagnosisTypically involves the temporal lobe Produces a granulomatous reaction in most casesIs of unknown etiologyCauses temporary neurological deficits that leads to death within a period of 8 to 12 years 9. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9Most common location for this finding is cerebellumThis feature is pathognomonic for this disease process It presents with rapidly progressing dementiaDefinitive diagnosis is by autopsyGross examination of the brain rarely provides any clues 10. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3It occurs due to problems within the 3rd month of gestationSpinal cord is unaffectedIt is usually associated with iris abnormalitiesCerebellum, brain stem and pituitary gland may be unaffectedIt is due to hindbrain abnormalities 11. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It is characterized by multiple lesions of various agesIt most commonly involves basal ganglia It is a dysmyelinating processIt is a rare disorder in this age groupPresents with typical initial neurological signs and symptoms 12. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13It has a high propensity to infiltrate the leptomeninges, since most arise in the cortexClear cytoplasm due to glycogen accumulation is typical Most are WHO Grade II; however, some can be WHO Grade IV Microcalcifications are helpful to the diagnosis, but are present in only 20 % of casesIf identified, losses of 1p and 19q indicate better response to treatment 13. Which of the following types of meningioma has the worst prognosis based on histological features?MetaplasticChordoidSecretoryRhabdoidFibroblastic 14. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12Typical gross appearance is a solid, well-circumscribed mass It is a relatively well-circumscribed tumor, rendering gross total resection possible It is considered as a WHO Grade II tumor It typically occurs in the cerebral hemispheres in the elderlyIn spite of gross total resection, the prognosis is grim 15. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?ToxoplasmosisCryptococcosisGlioblastomaChronic lymphocytic leukemiaMultiple sclerosis Loading...
