PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13Most are WHO Grade II; however, some can be WHO Grade IV Microcalcifications are helpful to the diagnosis, but are present in only 20 % of casesIf identified, losses of 1p and 19q indicate better response to treatment Clear cytoplasm due to glycogen accumulation is typical It has a high propensity to infiltrate the leptomeninges, since most arise in the cortex 2. Which of the following is correct regarding the central nervous system tumors?Hematogenous spread is common in high grade tumors due to vascular proliferation The annual incidence is 2/100,000 for intracranial tumors Biologic behavior does not necessarily correlate with histologyMeningioma is the most common primary brain tumor Supratentorial tumors are common in children 3. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3It is usually associated with iris abnormalitiesCerebellum, brain stem and pituitary gland may be unaffectedIt is due to hindbrain abnormalitiesIt occurs due to problems within the 3rd month of gestationSpinal cord is unaffected 4. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12Typical gross appearance is a solid, well-circumscribed mass It is considered as a WHO Grade II tumor In spite of gross total resection, the prognosis is grim It is a relatively well-circumscribed tumor, rendering gross total resection possible It typically occurs in the cerebral hemispheres in the elderly 5. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Requires electron microscopic examination for definitive diagnosisCauses temporary neurological deficits that leads to death within a period of 8 to 12 yearsProduces a granulomatous reaction in most casesTypically involves the temporal lobe Is of unknown etiology 6. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14The most common location is the pineal region of young adultsThis is a highly malignant tumor with 5-year survival rate of less than 10%Losses of 22p is the most common genetic alterationIt has a high propensity to infiltrate throughout the brain parenchymaThis is an undifferentiated tumor, although neuronal and glial markers can be expressed 7. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9Definitive diagnosis is by autopsyIt presents with rapidly progressing dementiaGross examination of the brain rarely provides any clues Most common location for this finding is cerebellumThis feature is pathognomonic for this disease process 8. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?ToxoplasmosisGlioblastomaChronic lymphocytic leukemiaMultiple sclerosis Cryptococcosis 9. Which of the following types of meningioma has the worst prognosis based on histological features?MetaplasticChordoidRhabdoidFibroblasticSecretory 10. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4Is a remote intraparenchymal hematoma secondary to traumaIs encephalomalacia due to trauma Is an acute hemorrhage An organized abscess cavity Is a remote infarct with hemorrhagic component 11. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It most commonly involves basal ganglia It is a dysmyelinating processPresents with typical initial neurological signs and symptomsIt is a rare disorder in this age groupIt is characterized by multiple lesions of various ages 12. Which of the following cell types originate outside the central nervous system?OligodendrogliocytesMicrogliocytesNeurons of the dentate gyrusAstrocytesEpendymocytes 13. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Can lead to cerebellar dysfunction in about 20% of casesIs reversible with intensive therapyIs the result of an acute intoxicationPredominantly affects granule cell layerIs the result of chronic methanol intoxication 14. Based on this image, this process: Neuropathology - Part 1, Question #7Evolves within a span of decades, with eventual deathIs primarily sporadicIs highly contagious among medical personnel Is difficult to suspect due to ill-defined clinical picture Is a specific form of viral encephalopathy 15. Which of the following is true regarding acute neuronal injury?Healing neurons can be identified as chromatolyticIt can be reversible if detected by brain biopsy It represents the typical injury pattern associated with toxic-metabolic insultsEosinophilic neuronal necrosis is the earliest light microscopic signRed neurons can be seen as early as 2 hours after injury Loading...
