PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following types of meningioma has the worst prognosis based on histological features?ChordoidRhabdoidFibroblasticMetaplasticSecretory 2. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14This is a highly malignant tumor with 5-year survival rate of less than 10%The most common location is the pineal region of young adultsLosses of 22p is the most common genetic alterationIt has a high propensity to infiltrate throughout the brain parenchymaThis is an undifferentiated tumor, although neuronal and glial markers can be expressed 3. Based on this image, this process: Neuropathology - Part 1, Question #7Evolves within a span of decades, with eventual deathIs highly contagious among medical personnel Is difficult to suspect due to ill-defined clinical picture Is primarily sporadicIs a specific form of viral encephalopathy 4. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4An organized abscess cavity Is a remote intraparenchymal hematoma secondary to traumaIs an acute hemorrhage Is encephalomalacia due to trauma Is a remote infarct with hemorrhagic component 5. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It is a dysmyelinating processIt is a rare disorder in this age groupIt is characterized by multiple lesions of various agesPresents with typical initial neurological signs and symptomsIt most commonly involves basal ganglia 6. Which of the following is correct regarding the central nervous system tumors?Hematogenous spread is common in high grade tumors due to vascular proliferation Biologic behavior does not necessarily correlate with histologyMeningioma is the most common primary brain tumor The annual incidence is 2/100,000 for intracranial tumors Supratentorial tumors are common in children 7. Which of the following is true regarding acute neuronal injury?Healing neurons can be identified as chromatolyticRed neurons can be seen as early as 2 hours after injury Eosinophilic neuronal necrosis is the earliest light microscopic signIt can be reversible if detected by brain biopsy It represents the typical injury pattern associated with toxic-metabolic insults 8. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3It occurs due to problems within the 3rd month of gestationSpinal cord is unaffectedIt is due to hindbrain abnormalitiesIt is usually associated with iris abnormalitiesCerebellum, brain stem and pituitary gland may be unaffected 9. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Is the result of an acute intoxicationPredominantly affects granule cell layerCan lead to cerebellar dysfunction in about 20% of casesIs reversible with intensive therapyIs the result of chronic methanol intoxication 10. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Produces a granulomatous reaction in most casesTypically involves the temporal lobe Is of unknown etiologyCauses temporary neurological deficits that leads to death within a period of 8 to 12 yearsRequires electron microscopic examination for definitive diagnosis 11. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12In spite of gross total resection, the prognosis is grim It is a relatively well-circumscribed tumor, rendering gross total resection possible Typical gross appearance is a solid, well-circumscribed mass It is considered as a WHO Grade II tumor It typically occurs in the cerebral hemispheres in the elderly 12. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?Chronic lymphocytic leukemiaGlioblastomaMultiple sclerosis CryptococcosisToxoplasmosis 13. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13If identified, losses of 1p and 19q indicate better response to treatment Most are WHO Grade II; however, some can be WHO Grade IV It has a high propensity to infiltrate the leptomeninges, since most arise in the cortexMicrocalcifications are helpful to the diagnosis, but are present in only 20 % of casesClear cytoplasm due to glycogen accumulation is typical 14. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9Most common location for this finding is cerebellumDefinitive diagnosis is by autopsyThis feature is pathognomonic for this disease process Gross examination of the brain rarely provides any clues It presents with rapidly progressing dementia 15. Which of the following cell types originate outside the central nervous system?Neurons of the dentate gyrusEpendymocytesAstrocytesMicrogliocytesOligodendrogliocytes Loading...
