PathMD Quizes, Neuropathology Neuropathology – 02 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following is correct regarding the lesion shown in this picture? Neuropathology Set 2It is the second most common type of intracranial aneurysm It is the most common cause of subarachnoid hemorrhageit is usually located at the bending points of arteries The most common location is posterior cerebral artery branches bleeding is typically associated with incipient leakage 2. Duret hemorrhages:are secondary to middle meningeal artery tearsare seen in midbrain and ponsare the most common cause of aqueductal stenosis occur in association with subfalcine herniationaccompany cerebellar mass lesions 3. Which of the following lesions may be found together with the lesion shown in the picture? (SEGCA) Neuropathology Set 2 Neuropathology Set 2Subungual angioma Pericardial cyst Renal cell carcinoma GlioblastomaCardiac rhabdomyoma 4. Which of the following is correct regarding HIV and central nervous system?opportunistic infections are more commonly seen in the pediatric patient population CJD caused by opportunistic JC virus infection is a rare but serious complication spinal cord involvement presents as transverse myelitis due to opportunistic Herpes virus infectionapproximately 60% of AIDS patients develop neurologic dysfuntion in the course of their diseasediagnostic feature is intense lymphocytic infiltrates in the brain parenchyma and in the leptomeninges 5. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2It is associated with one of the rarest form of genetic disorders It has a higher rate of progression to malignancy compared to general population It is associated with an autosomal-recessive disorder It is associated with an abnormality in 22q Bilateral schwannomas are also present in volving the 8th. nerve 6. Which of the following is correct regarding hypertensive central nervous system hemorrhage?periventricular white matter is the preferred site for hemorrhageit comprises approximately 1/3 of all intraparenchymal brain hemorrhagesCharcot-Bouchard aneurysms are thought to be the site of hemorrhage it is the second most common cause of subdural hemorrhage many cases are associated with congophilic angiopathy 7. Which of the following is true regarding pituitary adenomas?Growth hormone adenoma is the most common type Invasive adenomas have high probability of distant metastasesNelson syndrome is associated with gonadotroph adenomas Reticulin stain is a very useful technique for the differential diagnosis of normal pituitary gland vs. hyperplasia vs. adenoma Pituitary apoplexy is a postpartum neurosurgical emergency 8. Which of the following is true regarding the disease shown in the picture? Neuropathology Set 2it represents diffuse involvement of meninges by malignancyS. pneumoniae is the most common cause in adolescents cerebrospinal fluid shows increased lymphocytes and normal glucose levelE. coli is the most common cause in the elderly it may result in hydrocephalus 9. Which of the following is true regarding the disease process shown in the picture? Neuropathology Set 2This picture is most likely from caudate nucleus Structures with similar name, but with different microscopic appearance can be seen in cortical neurons and are easily demonstrated by synuclein immunohistochemistry This disease can easily be suspected in neonates by gross examinationIncrease in serotonin levels is the major abnormality This disease most commonly involves ageing neurons with lipofucsin pigment 10. Which of the following is true regarding neursyphilis?It occurs in the secondary stage of the disease Tabes dorsalis is the type that leads to dementia Meningovascular form is associated with obliterative endarteritis of the meninges Paretic neurosyphilis is aseptic and is an immune reaction to bacterial components Neurosyphilis occurs in approximately half of untreated and 10% of treated patients 11. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2 Neuropathology Set 2It is usually seen in the temporal lobe Cerebrospinal fluid dissemination is common 1p/19q losses indicate worse prognosis GFAP has a peculiar perinuclear positivitySpinal cord is the most common location in children 12. A 29 year old man was found dead in the street. Autopsy showed hemorrhage under occipital scalp, and contusions of both occipital poles. Which of the following is the most likely explanation?He was previously strangled to death and later the body was dumped in a remote street, at which time his head his the concrete pavement Slipped and fell on his back, hitting his head to concrete pavement Intracranial hemorrhage secondary to hypertensionHe was attacked and was hit on the back of his head by a baseball bat Metastatic lung cancer secondary to heavy smoking 13. While walking home after a party where he consumed five cans of beer, a previously healthy 28 year-old man fell and hit his head on the curb. He got up and went home. Later that night, he became unconscious and was brought to the emergency room by his roommate. Physical exam showed swelling of left temporalparietal area. What is the most likely explanation to his condition?Left meningeal artery ruptureLeft cerebral artery rupture Rupture of an anterior communicating artery aneurysmPreviously asymptomatic bacterial meningitis Right meningeal artery rupture 14. Which of the following is true regarding the lesion in this picture? Neuropathology Set 2It usually presents as a highly infiltrative tumor, but paradoxically has a good prognosis Its immunophenotype is essentially identical to renal cell carcinoma in many cases It is a highly malignant brain tumor with frequent dissemination to cerbrospinal axis It is typically located in the brainstem It may be associated with renal cell carcinoma 15. Which of the following pairs is correct?Kerns- Sayre syndrome- mitochondrial tRNA Metachromatic leukodystrophy- arylsulfatase A Adrenoleukodystrophy- long chain fatty acids Vitamin B1 deficiency- subacute combined degenration of the spinal cord Amyotrophic lateral sclerosis- trinucleotide repeats Loading...
