Lymph nodes have a similar morphology to MALT lymphomas with involvement of the marginal zones, but without extra nodal extension. 10-20% may transform to DLBCL. Bone marrow involvement is thought to occur in 30-60% of cases.
Immunophenotype
|
Marker
|
Comment
|
|
Negative
|
|
|
Positive
|
|
|
Positive
|
|
|
Positive
|
|
|
Negative
|
|
|
Negative
|
|
|
Negative
|
|
|
Positive
|
|
|
Negative
|
|
|
Low
|
|
|
MUM-1
|
Negative
|
|
Marginal zones contain FDC meshwork
|
|
|
Negative
|
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.