OCT-2

Octamer-binding transcription factor 2 (OCT-2) is a B-cell transcription factor (nuclear marker), which interacts with BOB.1 as a cotranscription factor for the activation of the immunoglobulin promoter in the process of immunoglobulin gene expression.

OCT-2 and BOB.1 are more commonly used to differentiate Classical Hodgkin Lymphoma (CHL) from Nodular Lymphocyte Predominate Hodgkin Lymphoma (NLPHL). In NLPHL both Oct-2 and BOB.1 are expressed. In CHL, however, only a subset of cells will express both Oct-2 and BOB.1.

OCT-2 and BOB.1 expression in lymphomas (Browne et al, consolidated published data)

Diagnosis	OCT-2	BOB.1
CHL	21/105 (20%)	25/74 (34%)
NLPHL	55/55 (100%)	40/40 (100%)
DLBCL	64/68 (94%)	47/47 (100%)
ALCL	2/13 (15%)	10/13 (77%)

Photomicrographs

OCT-2 NLPHL — OCT-2 expression in Nodular Lymphocyte Predominant Hodgkin Lymphoma

References

Browne P, Petrosyan K, Hernandez A, Chan JA. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol. 2003;120: 767–777. doi:10.1309/YCH8-DWUF-FQBK-GPVB

Stein H, Marafioti T, Foss HD, Laumen H, Hummel M, Anagnostopoulos I, et al. Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood. 2001;97: 496–501.

Chu PG, Loera S, Huang Q, Weiss LM. Lineage determination of CD20- B-Cell neoplasms: an immunohistochemical study. Am J Clin Pathol. 2006;126: 534–544. doi:10.1309/3WG32YRAMQ7RB9D4

McCune RC, Syrbu SI, Vasef MA. Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin“s and non-Hodgkin”s lymphomas: a comparative study using high throughput tissue microarrays. Mod Pathol. 2006;19: 1010–1018. doi:10.1038/modpathol.3800622