1. What is the approximate frequency of the sickle cell gene among the African American population?

2. The peripheral blood smear illustrated in Case #1 in the images below is from a young girl with recurrent infections. What is the most likely diagnosis:

3. A 44 y/o male presents to the ED with fever and shortness of breath. The peripheral blood smear illustrated in Case #2 in the images below represents which of the following:

4. A test using brilliant crystal blue and then evaluating blood smears at 10 minutes, 1 hour, and then 4 hours is used to evaluate for which of the following?

5. The blood smear illustrated in Case #3 in the images below is from a 13 y/o African American patient. Which of the following is the best diagnosis:

6. The cell illustrated in the image for Case #5 in the images below is best characterized as:

7. Which of the following is the most likely explanation of the findings in the images below:

8. A 35 y/o black woman with a Hb-5.2, MCV-63, and MCHC-28.2. A peripheral smear is reviewed and representative images are illustrated in Case #6 in the images below. The best diagnosis is:

9. The cell illustrated in the image for Case #4 in the images below is best characterized as:

10. All of the following are associated with a heterogeneous staining pattern in an acid elution test for fetal hemoglobin EXCEPT:

11. Which of the following is the best description of “Bart’s hemoglobin”?