Peripheral T-Cell Lymphoma, NOS (PTCL-NOS)

PTCL-NOS is a heterogeneous group of mature T-cell lymphoproliferative disorders, which do not fit well into other defined categories, and have a generally poor outcome.  While there may be a lot of variability to the IHC findings, the following are some general characteristics:
 
  • CD4>CD8 expression.
  • Frequent loss of antigen expression from T-cell markers (CD4, CD5, CD7, CD8, CD52)
  • CD30 is usually negative
  • CD56 is usually negative
  • CD10 is usually negative
  • CLCX13 – negative
  • BCL6 – negative
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.