PTCL-NOS is a heterogeneous group of mature T-cell lymphoproliferative disorders, which do not fit well into other defined categories, and have a generally poor outcome. While there may be a lot of variability to the IHC findings, the following are some general characteristics:
- CD4>CD8 expression.
- Frequent loss of antigen expression from T-cell markers (CD4, CD5, CD7, CD8, CD52)
- CD30 is usually negative
- CD56 is usually negative
- CD10 is usually negative
- CLCX13 – negative
- BCL6 – negative
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.