Podoplanin is a less common mesothelial and lymphatic marker that was originally used to identify glomerular structures (podocytes) in rats. It has similar perfomance characteristics to D2-40, but has less literature and experience available documenting sensitivity and specificity.
Expression Characteristics
- Lymphangiomas
- Lymphatic structures
- Kaposi’s Sarcoma
- Subset of angiosarcomas
- Epithelioid mesothelioma
Podoplanin is not expressed on vascular endothelium or adenocarcinomas.
References
Ordóñez NG. Immunohistochemical diagnosis of epithelioid mesothelioma: an update. Arch Pathol Lab Med. 2005;129: 1407–1414.
Mohammed RAA, Martin SG, Gill MS, Green AR, Paish EC, Ellis IO. Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences. Am J Surg Pathol. 2007;31: 1825–1833. doi:10.1097/PAS.0b013e31806841f6