Primary Cutaneous DLBCL, Leg Type

Primary Cutaneous DLBCL, Leg Type is an uncommon cutaneous lymphoma (<5% of cutaneous lymphomas), but and important entity to differentiate due to its aggressive course.  Unlike other cutaneous B-cell lymphomas, which are generally indolent and treated locally, primary cutaneous DLBCL, leg type behaves in a similar fashion to the systemic DLBCL (intermediate grade lymphoma) and is treated as such.

Characteristic Immunophenotype
Marker
Comment
Negative.  T-cells are generally absent or found in a perivascular pattern.
Positive
Positive
Strong expression in ~90% of cases.
Strong expression in ~90% of cases.
Expressed in a majority of cases.
Usually Negative
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 242.