Organ Systems, Lymph Node, WHO Classification

Primary Cutaneous Follicular Lymphoma 

  • Not related to nodal FL
  • t(14;18) not present.  If present, then should consider cutaneous involvement of a nodal FL.
  • Morphologically diverse (nodular to diffuse) with cells ranging from small lymphocytes to large centroblastic lymphoid cells.
  • BCL-6 +
  • CD10 and BCL-2 not consistently expressed

References
Fedoriw Y, Dogan A. The Expanding Spectrum of Follicular Lymphoma. Surg Pathol Clin. 2016;9: 29–40. doi:10.1016/j.path.2015.11.001
 
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127: 2375–2390. doi:10.1182/blood-2016-01-643569