Organ Systems, Bone Marrow, Lymph Node, WHO Classification

Primary Diffuse Large B-Cell Lymphoma of the CNS

October 10, 2017 peferguson

Primary CNS Lymphoma represents lymphoma restricted to the cerebral or ocular parenchyma. It represents <1% of non-Hodgkin lymphomas, and 2-3% of brain tumors.

Characteristic Immunophenotype

Marker	Comment
CD3	Negative
CD20	Positive
CD79a	Positive
CD22	Positive
CD10	Expressed in ~10-20% of cases.
Bcl-6	Expressed in 60-80% of cases.
MUM-1	Expressed in ~90% of cases.
Bcl-2	Expressed in most cases
EBV (EBER)	Usually Negative

References

Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 240-1.