PathMD Quizes, Renal Renal Medical – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. All of the following are causes of nephrotic syndrome EXCEPT:AmyloidosisMembranous glomerulopathy Acute infectious glomerulonephritis Focal segmental glomerulonephritis Minimal change disease 2. A 44 y/o white male with a h/o proteinuria since the age of 8 undergoes a renal biopsy. A representative microscopic image is shown below. Routine histology shows unremarkable glomeruli, and the Jones stain highlights patent capillaries with basement membranes of normal thickness. EM findings are available for review. The IF is negative and not shown. Based on the clinical history and renal biopsy findings, the best diagnosis is: Renal Medical - Part 2, Case #3 Renal Medical - Part 2, Case #3 Renal Medical - Part 2, Case #3 Renal Medical - Part 2, Case #3Membranous GN Thin Basement Membrane Disease Minimal Change Disease Focal Segmental Glomulonephropathy Secondary MPGN 3. A 29 y/o female with a h/o of Alport’s syndrome presents with increasing creatinine. The H&E and PAS histology from the renal biopsy are show below for review. Examination of the biopsy shows ATN with eosinophilic interstitial nephritis. On the H&E stains there are noted to be small blue amphophilic inclusions, which are highlighted on PAS. Base on the clinical history and the morphologic findings, the most likely diagnosis is: Renal Medical - Part 2, Case #2 Renal Medical - Part 2, Case #2 Renal Medical - Part 2, Case #2MalakoplakiaPolyomaHistoplasmosisCMV infection Cryptococcus 4. This renal disorder is characterized by a clinical association with respiratory infections or immunization and a prompt response to steroid therapy.Membranous GN Minimal change disease IgA nephropathyFocal Segmental GN Membranoproliferative GN 5. A 67 y/o male with a h/o MM presents with ARF. A renal bx. Is performed and the histology is show below for review. Based on the findings and the clinical history, the most likely diagnosis is: Renal Medical - Part 2, Case #1 Renal Medical - Part 2, Case #1 Renal Medical - Part 2, Case #1Acute Tubulo-interstitial nephritis Light Chain Deposition DiseaseAmyloidosisNephrocalcinosisAcute Tubular Necrosis 6. Which of the following are characteristic of nephritic syndrome?All of the answers are correctEdemaHypoalbuminemiaThrombosisHyperlipidemia 7. A patient presents with acute renal failure and hempotysis. A renal biopsy was performed and representative images are shown in the images below for review. Most notable are numerous crescents with >50% of the glomeruli being affected. Serologic studies showed a positive c-ANCA. IF is negative. Based on the clinical history, serologic findings and biopsy findings the best diagnosis is: Renal Medical - Part 2, Case #5 Renal Medical - Part 2, Case #5 Renal Medical - Part 2, Case #5Henoch-Schonlein purpura Goodpasture’s syndrome RPGN type IIIRPGN type I RPGN type II 8. A 57 y/o white female with a h/o multiple myeloma presents with acute renal failure. Representative histologic sections from the renal biopsy are on the website for review (images below). Based on the clinical history and biopsy findings, the best diagnosis is: Renal Medical - Part 2, Case #4 Renal Medical - Part 2, Case #4 Renal Medical - Part 2, Case #4 Renal Medical - Part 2, Case #4Fanconni’s syndromeNephrocalcinosisCast nephropathy AmyloidosisLight Chain Deposition Disease 9. Which of the following glomerulonephropathy is the most common cause of nephrotic syndrome in adults? It is characterized by diffuse thickening of the glomerulocapillary wall with electron dense deposits on the subepithelial side of the epithelial membrane.Membranoproliferative GN Membranous GNIgA nephropathy Minimal change disease Focal Segmental GN 10. This disease process is characterized by >50% of glomeruli with collapsed glomerular tufts and proliferation of Bowman’s capsule (crescents). Immunofluorescence is negative, but serum c-ANCA is positive. The best diagnosis is:Type I RPGN Type II RPGN Type I RPGN and Type III RPGN Type III RPGN All of the answers are correct Loading...