Spleen – 01

Author:  Philip Ferguson, M.D.

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1. Images for this case come from a spleen in a 60 year old male with a ruptured spleen. Special stains showed positivity for CD20, bcl-1, and CD43. Based on these findings, the best diagnosis is:

Spleen Part 1, Case #5
Spleen Part 1, Case #5


Spleen Part 1, Case #5
Spleen Part 1, Case #5


Spleen Part 1, Case #5
Spleen Part 1, Case #5
2. The images associated with this case are from a moderately enlarged spleen in an individual with a WBC count greater than 150,000. The flow cytometry profile showed the population to express CD13, CD33, and CD117. Based on the morphology and flow cytometry, the best diagnosis is:

Spleen Part 1, Case #1
Spleen Part 1, Case #1


Spleen Part 1, Case #1
Spleen Part 1, Case #1


Spleen Part 1, Case #1
Spleen Part 1, Case #1
3. These images are of a 1,000 gram spleen from a patient with multiple episodes of hemolysis resistant to steroids. Based on the images and the patient’s history, the best diagnosis is:

Spleen Part 1, Case #6
Spleen Part 1, Case #6


Spleen Part 1, Case #6
4. The images for this case come from a 60 year old man with an enlarged spleen and a hilar mass. Based on the information, the best diagnosis is:

Spleen Part 1, Case #3
Spleen Part 1, Case #3


Spleen Part 1, Case #3
Spleen Part 1, Case #3


Spleen Part 1, Case #3
Spleen Part 1, Case #3
5. The images for this case are from a 1,000 gram spleen from a 75 year old man. Special stains were positive for CD45 and CD20, but negative for CD3 and CD15. Based on these findings, the best diagnosis is:

Spleen Part 1, Case #8
Spleen Part 1, Case #8


Spleen Part 1, Case #8
Spleen Part 1, Case #8


Spleen Part 1, Case #8
Spleen Part 1, Case #8
6. A 4,000 gram spleen was removed from a man and has the histology presented for this case in the images below. Special stains were performed. The cells of interest were positive for CD68 and negative for S-100, CD1a, and PAS. Based on these findings, the best diagnosis is:

Spleen Part 1, Case #2
Spleen Part 1, Case #2


Spleen Part 1, Case #2
Spleen Part 1, Case #2


Spleen Part 1, Case #2
Spleen Part 1, Case #2
7. The images for this case come from an elderly female with a history of an autoimmune disorder. The spleen was 1,500 grams and noted to have “tumor nodules”. Based on the findings, the best diagnosis is:

Spleen Part 1, Case #4
Spleen Part 1, Case #4


Spleen Part 1, Case #4
Spleen Part 1, Case #4


Spleen Part 1, Case #4
Spleen Part 1, Case #4
8. These images are from the spleen of a 30 y/o pregnant patient. The spleen weighed 2,000 grams. Stains for AFB and fungi were negative. The best diagnosis is:

Spleen Part 1, Case #7
Spleen Part 1, Case #7


Spleen Part 1, Case #7
Spleen Part 1, Case #7