PathMD Quizes, Hematopathology Spleen – 01 October 29, 2017 peferguson Author: Philip Ferguson, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Images for this case come from a spleen in a 60 year old male with a ruptured spleen. Special stains showed positivity for CD20, bcl-1, and CD43. Based on these findings, the best diagnosis is: Spleen Part 1, Case #5 Spleen Part 1, Case #5 Spleen Part 1, Case #5Mantle Cell Lymphoma Follicular Lymphoma CLL/SLLDiffuse Large B-Cell LymphomaMarginal Zone Lymphoma 2. The images associated with this case are from a moderately enlarged spleen in an individual with a WBC count greater than 150,000. The flow cytometry profile showed the population to express CD13, CD33, and CD117. Based on the morphology and flow cytometry, the best diagnosis is: Spleen Part 1, Case #1 Spleen Part 1, Case #1 Spleen Part 1, Case #1Hairy Cell Leukemia CMLALLAMLCLL/SLL 3. These images are of a 1,000 gram spleen from a patient with multiple episodes of hemolysis resistant to steroids. Based on the images and the patient’s history, the best diagnosis is: Spleen Part 1, Case #6 Spleen Part 1, Case #6Congestion secondary to increased venous pressureKasabach-Merritt phenomenonFelty syndromeCongestion secondary to AIHA 4. The images for this case come from a 60 year old man with an enlarged spleen and a hilar mass. Based on the information, the best diagnosis is: Spleen Part 1, Case #3 Spleen Part 1, Case #3 Spleen Part 1, Case #3MelanomaLarge Cell Neuroendocrine Carcinoma Anaplastic Large Cell Lymphoma Hodgkin’s Lymphoma Large Cell Lymphoma 5. The images for this case are from a 1,000 gram spleen from a 75 year old man. Special stains were positive for CD45 and CD20, but negative for CD3 and CD15. Based on these findings, the best diagnosis is: Spleen Part 1, Case #8 Spleen Part 1, Case #8 Spleen Part 1, Case #8Anaplastic Large Cell LymphomaMelanomaHodgkin’s Lymphoma Anaplastic DLBCL Immunoblastic DLBCL 6. A 4,000 gram spleen was removed from a man and has the histology presented for this case in the images below. Special stains were performed. The cells of interest were positive for CD68 and negative for S-100, CD1a, and PAS. Based on these findings, the best diagnosis is: Spleen Part 1, Case #2 Spleen Part 1, Case #2 Spleen Part 1, Case #2Rosai-Dorfman disease Gaucher diseaseLangerhan Cell Histiocytosis Splenic Marginal Zone LymphomaWhipple’s disease 7. The images for this case come from an elderly female with a history of an autoimmune disorder. The spleen was 1,500 grams and noted to have “tumor nodules”. Based on the findings, the best diagnosis is: Spleen Part 1, Case #4 Spleen Part 1, Case #4 Spleen Part 1, Case #4Littoral Cell Angioma AngiosarcomaLeiomyosarcomaHemangiomaKaposi’s Sarcoma 8. These images are from the spleen of a 30 y/o pregnant patient. The spleen weighed 2,000 grams. Stains for AFB and fungi were negative. The best diagnosis is: Spleen Part 1, Case #7 Spleen Part 1, Case #7Necrotizing granulomatous splenitis AmyloidosisLeishmaniasisTBSarcoidosis Loading...