Immunohistochemistry
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Positive
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Positive
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Usually Positive (~70%)
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Variable (~50%)
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It is important to remember that gastric adenocarcinomas may have almost any combination of CK7/CK20 expression!
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Usually negative
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CK5/6
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Usually negative
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Variably Positive. Studies show a wide range of positivity.
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+/-
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Dim nuclear staining is well-described.
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HepPar-1, AFP, Chromogranin, and Synaptophysin have been shown to stain some cases. Clinical and morphologic context must be appreciated at all times and resolved with the IHC findings. Be careful in performing too many stains, or the “tail may be wagging the dog” so to speak.