T-PLL is an aggressive T-cell leukemia composed of small to medium-sized post-thymic T-cells, which usually have a nucleolus (Up to 25% of cases may not have visible nucleoli). Most patients will have generalized lymphadenopathy in addition to hepatosplenomegaly. Up to 20% of cases will have skin involvement.
Charateristic Immunophenotypic Profile
Stain
|
Comment
|
Negative
|
|
Negative
|
|
Positive
|
|
Positive
|
|
Positive
|
|
CD4+/CD8-
CD4+/CD8+
CD4-/CD8+
|
~60% of cases
~25% of cases
~15% of cases
|
TCL1
|
Positive
|
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.