T-Cell Prolymphocytic Leukemia (T-PLL)

T-PLL is an aggressive T-cell leukemia composed of small to medium-sized post-thymic T-cells, which usually have a nucleolus (Up to 25% of cases may not have visible nucleoli).  Most patients will have generalized lymphadenopathy in addition to hepatosplenomegaly.  Up to 20% of cases will have skin involvement.
Charateristic Immunophenotypic Profile
 
Stain
Comment
Negative
Negative
Positive
Positive
Positive
CD4+/CD8-
CD4+/CD8+
CD4-/CD8+
~60% of cases
~25% of cases
~15% of cases
TCL1
Positive
References
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.